Risk of development of gastric carcinoma in patients with pernicious anemia: A population-based study in Rochester, Minnesota

L. W. Schafer, D. E. Larson, L. J. Melton, J. A. Higgins, A. R. Zinsmeister

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95% confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia.

Original languageEnglish (US)
Pages (from-to)444-448
Number of pages5
JournalMayo Clinic Proceedings
Volume60
Issue number7
StatePublished - 1985

Fingerprint

Pernicious Anemia
Stomach
Stomach Neoplasms
Carcinoma
Population
Incidence
Observation
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Schafer, L. W., Larson, D. E., Melton, L. J., Higgins, J. A., & Zinsmeister, A. R. (1985). Risk of development of gastric carcinoma in patients with pernicious anemia: A population-based study in Rochester, Minnesota. Mayo Clinic Proceedings, 60(7), 444-448.

Risk of development of gastric carcinoma in patients with pernicious anemia : A population-based study in Rochester, Minnesota. / Schafer, L. W.; Larson, D. E.; Melton, L. J.; Higgins, J. A.; Zinsmeister, A. R.

In: Mayo Clinic Proceedings, Vol. 60, No. 7, 1985, p. 444-448.

Research output: Contribution to journalArticle

Schafer, LW, Larson, DE, Melton, LJ, Higgins, JA & Zinsmeister, AR 1985, 'Risk of development of gastric carcinoma in patients with pernicious anemia: A population-based study in Rochester, Minnesota', Mayo Clinic Proceedings, vol. 60, no. 7, pp. 444-448.
Schafer, L. W. ; Larson, D. E. ; Melton, L. J. ; Higgins, J. A. ; Zinsmeister, A. R. / Risk of development of gastric carcinoma in patients with pernicious anemia : A population-based study in Rochester, Minnesota. In: Mayo Clinic Proceedings. 1985 ; Vol. 60, No. 7. pp. 444-448.
@article{ae72061c55a64e1fbb081fdd48653caf,
title = "Risk of development of gastric carcinoma in patients with pernicious anemia: A population-based study in Rochester, Minnesota",
abstract = "To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95{\%} confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia.",
author = "Schafer, {L. W.} and Larson, {D. E.} and Melton, {L. J.} and Higgins, {J. A.} and Zinsmeister, {A. R.}",
year = "1985",
language = "English (US)",
volume = "60",
pages = "444--448",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "7",

}

TY - JOUR

T1 - Risk of development of gastric carcinoma in patients with pernicious anemia

T2 - A population-based study in Rochester, Minnesota

AU - Schafer, L. W.

AU - Larson, D. E.

AU - Melton, L. J.

AU - Higgins, J. A.

AU - Zinsmeister, A. R.

PY - 1985

Y1 - 1985

N2 - To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95% confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia.

AB - To determine the long-term risk of the development of gastric cancer among patients with pernicious anemia, we identified the 152 residents of Rochester, Minnesota, who had well-documented pernicious anemia during the 30-year period 1950 through 1979. These patients were subsequently followed up for more than 1,550 person-years of observation. The observed risk of the development of a gastric cancer in this cohort was compared with that expected on the basis of incidence rates of gastric cancer for the local population. We found one case of gastric carcinoma among our 152 patients with pernicious anemia as compared with an expected incidence of 1.02 (relative risk, 1.0; 95% confidence interval, 0.02 through 5.5). We conclude that no strong indication exists for either radiographic or endoscopic surveillance in asymptomatic patients with pernicious anemia.

UR - http://www.scopus.com/inward/record.url?scp=0022258153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022258153&partnerID=8YFLogxK

M3 - Article

C2 - 4010342

AN - SCOPUS:0022258153

VL - 60

SP - 444

EP - 448

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 7

ER -