TY - JOUR
T1 - Risk of dementia in stroke-free patients diagnosed with atrial fibrillation
T2 - Data from a community-based cohort
AU - Miyasaka, Yoko
AU - Barnes, Marion E.
AU - Petersen, Ronald C.
AU - Cha, Stephen S.
AU - Bailey, Kent R.
AU - Gersh, Bernard J.
AU - Casaclang-Verzosa, Grace
AU - Abhayaratna, Walter P.
AU - Seward, James B.
AU - Iwasaka, Toshiji
AU - Tsang, Teresa S.M.
N1 - Funding Information:
This study was supported by the American Heart Association National Scientist Development Grant. There is no financial conflict on the part of any of the authors.
PY - 2007/8
Y1 - 2007/8
N2 - Aims: To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. Methods and results: Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detection of dementia. Interim stroke was censored in the analyses. Of 2837 subjects (71 ± 15 years old) diagnosed with first AF and without any evidence of cognitive dysfunction or stroke at the time of AF onset, 299 were diagnosed with dementia during a median follow-up of 4.6 years [interquartile (IQR) range 1.5-7.9 years], and 1638 died. The Kaplan-Meier cumulative rate of dementia was 2.7% at 1 year and 10.5% at 5 years. After adjustment for age and sex, dementia was strongly related to advancing age [hazard ratio (HR)/10 years, 2.8; 95% confidence interval (CI), 2.5-3.2], but did not vary with sex (P = 0.52). The occurrence of post-AF dementia was associated with significantly increased mortality risk (HR 2.9; 95% CI 2.5-3.3), even after adjustment for multiple comorbidities, and did not vary with age (P = 0.75) or sex (P = 0.33). Conclusion: Dementia appeared common following the diagnosis of first AF, and was associated with premature death.
AB - Aims: To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. Methods and results: Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detection of dementia. Interim stroke was censored in the analyses. Of 2837 subjects (71 ± 15 years old) diagnosed with first AF and without any evidence of cognitive dysfunction or stroke at the time of AF onset, 299 were diagnosed with dementia during a median follow-up of 4.6 years [interquartile (IQR) range 1.5-7.9 years], and 1638 died. The Kaplan-Meier cumulative rate of dementia was 2.7% at 1 year and 10.5% at 5 years. After adjustment for age and sex, dementia was strongly related to advancing age [hazard ratio (HR)/10 years, 2.8; 95% confidence interval (CI), 2.5-3.2], but did not vary with sex (P = 0.52). The occurrence of post-AF dementia was associated with significantly increased mortality risk (HR 2.9; 95% CI 2.5-3.3), even after adjustment for multiple comorbidities, and did not vary with age (P = 0.75) or sex (P = 0.33). Conclusion: Dementia appeared common following the diagnosis of first AF, and was associated with premature death.
KW - Atrial fibrillation
KW - Dementia
KW - Incidence
KW - Prognosis
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U2 - 10.1093/eurheartj/ehm012
DO - 10.1093/eurheartj/ehm012
M3 - Article
C2 - 17459900
AN - SCOPUS:35348908030
SN - 0195-668X
VL - 28
SP - 1962
EP - 1967
JO - European heart journal
JF - European heart journal
IS - 16
ER -