Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: Data from a community-based cohort

Yoko Miyasaka, Marion E. Barnes, Ronald C. Petersen, Stephen S. Cha, Kent R. Bailey, Bernard J. Gersh, Grace Casaclang-Verzosa, Walter P. Abhayaratna, James B. Seward, Toshiji Iwasaka, Teresa S.M. Tsang

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Aims: To estimate the incidence of dementia after the first atrial fibrillation (AF), and its impact on survival in a community-based cohort. Methods and results: Olmsted County, Minnesota adult residents diagnosed with first AF during 1986-2000 were identified, and followed until 2004. The primary outcome was new detection of dementia. Interim stroke was censored in the analyses. Of 2837 subjects (71 ± 15 years old) diagnosed with first AF and without any evidence of cognitive dysfunction or stroke at the time of AF onset, 299 were diagnosed with dementia during a median follow-up of 4.6 years [interquartile (IQR) range 1.5-7.9 years], and 1638 died. The Kaplan-Meier cumulative rate of dementia was 2.7% at 1 year and 10.5% at 5 years. After adjustment for age and sex, dementia was strongly related to advancing age [hazard ratio (HR)/10 years, 2.8; 95% confidence interval (CI), 2.5-3.2], but did not vary with sex (P = 0.52). The occurrence of post-AF dementia was associated with significantly increased mortality risk (HR 2.9; 95% CI 2.5-3.3), even after adjustment for multiple comorbidities, and did not vary with age (P = 0.75) or sex (P = 0.33). Conclusion: Dementia appeared common following the diagnosis of first AF, and was associated with premature death.

Original languageEnglish (US)
Pages (from-to)1962-1967
Number of pages6
JournalEuropean heart journal
Volume28
Issue number16
DOIs
StatePublished - Aug 1 2007

Keywords

  • Atrial fibrillation
  • Dementia
  • Incidence
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Miyasaka, Y., Barnes, M. E., Petersen, R. C., Cha, S. S., Bailey, K. R., Gersh, B. J., Casaclang-Verzosa, G., Abhayaratna, W. P., Seward, J. B., Iwasaka, T., & Tsang, T. S. M. (2007). Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: Data from a community-based cohort. European heart journal, 28(16), 1962-1967. https://doi.org/10.1093/eurheartj/ehm012