Risk of cardiovascular events in patients with polycystic ovary syndrome

S. Iftikhar, M. L. Collazo-Clavell, Veronique Lee Roger, Jennifer St. Sauver, Robert D Jr. Brown, S. Cha, Deborah Rhodes

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Women with polycystic ovary syndrome (PCOS) have increased prevalence of cardiovascular (CV) risk factors. However, data on the incidence of CV events are lacking in this population. Using Rochester Epidemiology Project resources, we conducted a retrospective cohort study comparing CV events in women with PCOS with those of women without PCOS in Olmsted County, Minnesota. Between 1966 and 1988, 309 women with PCOS and 343 without PCOS were identified. Mean (SD) age at PCOS diagnosis was 25.0 (5.3) years; mean age at last follow-up was 46.7 years. Mean (SD) follow-up was 23.7 (13.7) years. Women with PCOS had a higher body mass index (29.4 kg/m2 vs 28.3 kg/m2; p=.01). Prevalence of type 2 diabetes mellitus and hypertension and levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides were similar in the two groups. We observed no increase in CV events, including myocardial infarction (adjusted hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.32 to 1.72; p=.48); coronary artery bypass graft surgery (adjusted HR 1.52; 95% CI 0.42 to 5.48; p=.52); death (adjusted HR 1.03; 95% CI, 0.29 to 3.71; p=.96); death due to CV disease (adjusted HR 5.67; 95% CI 0.51 to 63.7; p=.16); or stroke (adjusted HR 1.05; 95% CI 0.28 to 3.92; p=.94). Although women with PCOS weighed more than controls, there was no increased prevalence of other CV risk factors. Furthermore, we found no increase in CV events. While prospective studies are needed to confirm these findings, women with PCOS do not appear to have adverse CV outcomes in midlife.

Original languageEnglish (US)
Pages (from-to)74-80
Number of pages7
JournalNetherlands Journal of Medicine
Volume70
Issue number2
StatePublished - Feb 2012

Fingerprint

Polycystic Ovary Syndrome
Confidence Intervals
Coronary Artery Bypass
LDL Cholesterol
Type 2 Diabetes Mellitus
HDL Cholesterol
Epidemiology
Body Mass Index
Cohort Studies
Cardiovascular Diseases
Retrospective Studies
Stroke
Myocardial Infarction
Cholesterol
Prospective Studies
Hypertension
Transplants
Incidence

Keywords

  • Cardiovascular disease
  • Polycystic ovary syndrome
  • Rochester epidemiology project

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Risk of cardiovascular events in patients with polycystic ovary syndrome. / Iftikhar, S.; Collazo-Clavell, M. L.; Roger, Veronique Lee; St. Sauver, Jennifer; Brown, Robert D Jr.; Cha, S.; Rhodes, Deborah.

In: Netherlands Journal of Medicine, Vol. 70, No. 2, 02.2012, p. 74-80.

Research output: Contribution to journalArticle

@article{ae9ef5b7682148619985a43aa7db93d8,
title = "Risk of cardiovascular events in patients with polycystic ovary syndrome",
abstract = "Women with polycystic ovary syndrome (PCOS) have increased prevalence of cardiovascular (CV) risk factors. However, data on the incidence of CV events are lacking in this population. Using Rochester Epidemiology Project resources, we conducted a retrospective cohort study comparing CV events in women with PCOS with those of women without PCOS in Olmsted County, Minnesota. Between 1966 and 1988, 309 women with PCOS and 343 without PCOS were identified. Mean (SD) age at PCOS diagnosis was 25.0 (5.3) years; mean age at last follow-up was 46.7 years. Mean (SD) follow-up was 23.7 (13.7) years. Women with PCOS had a higher body mass index (29.4 kg/m2 vs 28.3 kg/m2; p=.01). Prevalence of type 2 diabetes mellitus and hypertension and levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides were similar in the two groups. We observed no increase in CV events, including myocardial infarction (adjusted hazard ratio [HR] 0.74; 95{\%} confidence interval [CI] 0.32 to 1.72; p=.48); coronary artery bypass graft surgery (adjusted HR 1.52; 95{\%} CI 0.42 to 5.48; p=.52); death (adjusted HR 1.03; 95{\%} CI, 0.29 to 3.71; p=.96); death due to CV disease (adjusted HR 5.67; 95{\%} CI 0.51 to 63.7; p=.16); or stroke (adjusted HR 1.05; 95{\%} CI 0.28 to 3.92; p=.94). Although women with PCOS weighed more than controls, there was no increased prevalence of other CV risk factors. Furthermore, we found no increase in CV events. While prospective studies are needed to confirm these findings, women with PCOS do not appear to have adverse CV outcomes in midlife.",
keywords = "Cardiovascular disease, Polycystic ovary syndrome, Rochester epidemiology project",
author = "S. Iftikhar and Collazo-Clavell, {M. L.} and Roger, {Veronique Lee} and {St. Sauver}, Jennifer and Brown, {Robert D Jr.} and S. Cha and Deborah Rhodes",
year = "2012",
month = "2",
language = "English (US)",
volume = "70",
pages = "74--80",
journal = "Netherlands Journal of Medicine",
issn = "0300-2977",
publisher = "Van Zuiden Communications BV",
number = "2",

}

TY - JOUR

T1 - Risk of cardiovascular events in patients with polycystic ovary syndrome

AU - Iftikhar, S.

AU - Collazo-Clavell, M. L.

AU - Roger, Veronique Lee

AU - St. Sauver, Jennifer

AU - Brown, Robert D Jr.

AU - Cha, S.

AU - Rhodes, Deborah

PY - 2012/2

Y1 - 2012/2

N2 - Women with polycystic ovary syndrome (PCOS) have increased prevalence of cardiovascular (CV) risk factors. However, data on the incidence of CV events are lacking in this population. Using Rochester Epidemiology Project resources, we conducted a retrospective cohort study comparing CV events in women with PCOS with those of women without PCOS in Olmsted County, Minnesota. Between 1966 and 1988, 309 women with PCOS and 343 without PCOS were identified. Mean (SD) age at PCOS diagnosis was 25.0 (5.3) years; mean age at last follow-up was 46.7 years. Mean (SD) follow-up was 23.7 (13.7) years. Women with PCOS had a higher body mass index (29.4 kg/m2 vs 28.3 kg/m2; p=.01). Prevalence of type 2 diabetes mellitus and hypertension and levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides were similar in the two groups. We observed no increase in CV events, including myocardial infarction (adjusted hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.32 to 1.72; p=.48); coronary artery bypass graft surgery (adjusted HR 1.52; 95% CI 0.42 to 5.48; p=.52); death (adjusted HR 1.03; 95% CI, 0.29 to 3.71; p=.96); death due to CV disease (adjusted HR 5.67; 95% CI 0.51 to 63.7; p=.16); or stroke (adjusted HR 1.05; 95% CI 0.28 to 3.92; p=.94). Although women with PCOS weighed more than controls, there was no increased prevalence of other CV risk factors. Furthermore, we found no increase in CV events. While prospective studies are needed to confirm these findings, women with PCOS do not appear to have adverse CV outcomes in midlife.

AB - Women with polycystic ovary syndrome (PCOS) have increased prevalence of cardiovascular (CV) risk factors. However, data on the incidence of CV events are lacking in this population. Using Rochester Epidemiology Project resources, we conducted a retrospective cohort study comparing CV events in women with PCOS with those of women without PCOS in Olmsted County, Minnesota. Between 1966 and 1988, 309 women with PCOS and 343 without PCOS were identified. Mean (SD) age at PCOS diagnosis was 25.0 (5.3) years; mean age at last follow-up was 46.7 years. Mean (SD) follow-up was 23.7 (13.7) years. Women with PCOS had a higher body mass index (29.4 kg/m2 vs 28.3 kg/m2; p=.01). Prevalence of type 2 diabetes mellitus and hypertension and levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides were similar in the two groups. We observed no increase in CV events, including myocardial infarction (adjusted hazard ratio [HR] 0.74; 95% confidence interval [CI] 0.32 to 1.72; p=.48); coronary artery bypass graft surgery (adjusted HR 1.52; 95% CI 0.42 to 5.48; p=.52); death (adjusted HR 1.03; 95% CI, 0.29 to 3.71; p=.96); death due to CV disease (adjusted HR 5.67; 95% CI 0.51 to 63.7; p=.16); or stroke (adjusted HR 1.05; 95% CI 0.28 to 3.92; p=.94). Although women with PCOS weighed more than controls, there was no increased prevalence of other CV risk factors. Furthermore, we found no increase in CV events. While prospective studies are needed to confirm these findings, women with PCOS do not appear to have adverse CV outcomes in midlife.

KW - Cardiovascular disease

KW - Polycystic ovary syndrome

KW - Rochester epidemiology project

UR - http://www.scopus.com/inward/record.url?scp=84863364380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863364380&partnerID=8YFLogxK

M3 - Article

C2 - 22418753

AN - SCOPUS:84863364380

VL - 70

SP - 74

EP - 80

JO - Netherlands Journal of Medicine

JF - Netherlands Journal of Medicine

SN - 0300-2977

IS - 2

ER -