Risk of cancer after herpes zoster. A population-based study

M. W. Ragozzino, L. J. Melton, L. T. Kurland, C. P. Chu, H. O. Perry

Research output: Contribution to journalArticle

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Abstract

Herpes zoster has been associated with immune suppression, as has an increased risk of cancer. To determine whether patients with herpes zoster are at increased risk for subsequent cancer, we followed 590 residents of Rochester, Minnesota, for 9389 person-years after the diagnosis of herpes zoster. Subsequent relative cancr risks, overall and by specific site, were determined for the entire cohort and selected subgroups. In addition, relative risks of cancer during various intervals after the diagnosis of herpes zoster were determined. The overall risk was 1.1 (95 per cent confidence interval, 0.9 to 1.3). Relative risks for specific cancer sites were not different from unity except for those for colon and bladder tumors in women, both of which were slightly elevated. Patients with disseminated, recurrent, or gangrenous zoster, with postherpatic neuralgia, and with ophthalmic zoster were not at elevated risk for subsequent cancer. These findings do not support the investigation of patients for occult cancer at the time of diagnosis of herpes zoster or enhanced surveillance for cancer after such a diagnosis.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalNew England Journal of Medicine
Volume307
Issue number7
StatePublished - 1982

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Herpes Zoster
Population
Neoplasms
Neuralgia
Urinary Bladder Neoplasms
Colon
Confidence Intervals

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ragozzino, M. W., Melton, L. J., Kurland, L. T., Chu, C. P., & Perry, H. O. (1982). Risk of cancer after herpes zoster. A population-based study. New England Journal of Medicine, 307(7), 393-397.

Risk of cancer after herpes zoster. A population-based study. / Ragozzino, M. W.; Melton, L. J.; Kurland, L. T.; Chu, C. P.; Perry, H. O.

In: New England Journal of Medicine, Vol. 307, No. 7, 1982, p. 393-397.

Research output: Contribution to journalArticle

Ragozzino, MW, Melton, LJ, Kurland, LT, Chu, CP & Perry, HO 1982, 'Risk of cancer after herpes zoster. A population-based study', New England Journal of Medicine, vol. 307, no. 7, pp. 393-397.
Ragozzino MW, Melton LJ, Kurland LT, Chu CP, Perry HO. Risk of cancer after herpes zoster. A population-based study. New England Journal of Medicine. 1982;307(7):393-397.
Ragozzino, M. W. ; Melton, L. J. ; Kurland, L. T. ; Chu, C. P. ; Perry, H. O. / Risk of cancer after herpes zoster. A population-based study. In: New England Journal of Medicine. 1982 ; Vol. 307, No. 7. pp. 393-397.
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