Risk of acute leukemia and myelodysplastic syndromes in patients with monoclonal gammopathy of undetermined significance (MGUS): A population-based study of 17 315 patients

L. E. Roeker; D. R. Larson; R. A. Kyle; S. Kumar; A. Dispenzieri; S. V. Rajkumar

doi:10.1038/leu.2013.34

Risk of acute leukemia and myelodysplastic syndromes in patients with monoclonal gammopathy of undetermined significance (MGUS): A population-based study of 17 315 patients

L. E. Roeker, D. R. Larson, R. A. Kyle, S. Kumar, A. Dispenzieri, S. V. Rajkumar

Hematology

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The purpose of this study was to determine if there is an increased risk of acute leukemia and myelodysplastic syndromes (MDS) in persons with monoclonal gammopathy of undetermined significance (MGUS). We used a large population-based cohort of individuals systematically screened for the presence or absence of MGUS. MGUS status was then linked to the diagnosis of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and MDS. A total of 17 315 patients age 50 and older (605 MGUS and 16 710 controls) with a cumulative 435 021 person-years of follow-up were studied. MGUS patients had a significantly higher risk of developing MDS compared with controls, hazard ratio 2.4 (95% CI 1.08, 5.32), P=0.031. There was no statistically significant increase in the risk of AML (RR 1.36 P=0.675), and no increased risk of developing ALL.

Original language	English (US)
Pages (from-to)	1391-1393
Number of pages	3
Journal	Leukemia
Volume	27
Issue number	6
DOIs	https://doi.org/10.1038/leu.2013.34
State	Published - Jun 2013

Keywords

MGUS
acute leukemias
monoclonal gammopathy of undetermined significance
myelodysplastic syndromes
population-based screening

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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title = "Risk of acute leukemia and myelodysplastic syndromes in patients with monoclonal gammopathy of undetermined significance (MGUS): A population-based study of 17 315 patients",

abstract = "The purpose of this study was to determine if there is an increased risk of acute leukemia and myelodysplastic syndromes (MDS) in persons with monoclonal gammopathy of undetermined significance (MGUS). We used a large population-based cohort of individuals systematically screened for the presence or absence of MGUS. MGUS status was then linked to the diagnosis of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and MDS. A total of 17 315 patients age 50 and older (605 MGUS and 16 710 controls) with a cumulative 435 021 person-years of follow-up were studied. MGUS patients had a significantly higher risk of developing MDS compared with controls, hazard ratio 2.4 (95% CI 1.08, 5.32), P=0.031. There was no statistically significant increase in the risk of AML (RR 1.36 P=0.675), and no increased risk of developing ALL.",

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author = "Roeker, {L. E.} and Larson, {D. R.} and Kyle, {R. A.} and S. Kumar and A. Dispenzieri and Rajkumar, {S. V.}",

note = "Funding Information: This work was supported in part by the National Cancer Institute, National Institutes of Health, Bethesda, MD (CA107476, CA168762, CA100707, CA 83724). Also supported in part by the Jabbs Foundation, Birmingham, United Kingdom and the Henry J. Predolin Foundation, USA.",

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AU - Larson, D. R.

AU - Kyle, R. A.

AU - Kumar, S.

AU - Dispenzieri, A.

AU - Rajkumar, S. V.

N1 - Funding Information: This work was supported in part by the National Cancer Institute, National Institutes of Health, Bethesda, MD (CA107476, CA168762, CA100707, CA 83724). Also supported in part by the Jabbs Foundation, Birmingham, United Kingdom and the Henry J. Predolin Foundation, USA.

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AB - The purpose of this study was to determine if there is an increased risk of acute leukemia and myelodysplastic syndromes (MDS) in persons with monoclonal gammopathy of undetermined significance (MGUS). We used a large population-based cohort of individuals systematically screened for the presence or absence of MGUS. MGUS status was then linked to the diagnosis of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and MDS. A total of 17 315 patients age 50 and older (605 MGUS and 16 710 controls) with a cumulative 435 021 person-years of follow-up were studied. MGUS patients had a significantly higher risk of developing MDS compared with controls, hazard ratio 2.4 (95% CI 1.08, 5.32), P=0.031. There was no statistically significant increase in the risk of AML (RR 1.36 P=0.675), and no increased risk of developing ALL.

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Risk of acute leukemia and myelodysplastic syndromes in patients with monoclonal gammopathy of undetermined significance (MGUS): A population-based study of 17 315 patients

Abstract

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