TY - JOUR
T1 - Risk factors for spinal osteoporosis in men
AU - Seeman, Ego
AU - Melton, L. Joseph
AU - O'Fallon, W. Michael
AU - Riggs, B. Lawrence
N1 - Funding Information:
From the Endocrinology Research Unit, Division of Endocrinology, Metabolism, and Internal Medicine, and the Department of Medical Statistics and Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota. This investigation was supported in part by Research Grant AM-27065 from the National Institutes of Health, Public Health Service. Requests for reprints should be addressed to Dr. L. Joseph Melton Ill, Department of Medical Statistics and Epidemiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55905. Manuscript accepted April 20, 1983. l Current address: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia 3084.
PY - 1983/12
Y1 - 1983/12
N2 - Risk factors for vertebral fractures due to osteoporosis were evaluated in 105 consecutive male patients over a four-year period. An equal number of men with Paget's disease, matched by age, who concurrently attended the same subspecialty clinic served as control subjects. The relative risk for osteoporosis, estimated by the odds ratio, was increased among those who smoke cigarettes (relative risk = 2.3; p = 0.01), drank alcoholic beverages (relative risk = 2.4; p = 0.02), or had an associated medical disease known to affect calcium or bone metabolism (relative risk = 5.5; p < 0.001). Obesity was protective (relative risk = 0.3; p < 0.001). As assessed by a multiple logistic model, the risk associated with smoking and drinking increased with age. The effects of these four major risk factors were largely independent of one another and were cumulative. Thus, spinal osteoporosis in men is frequently associated with recognizable risk factors, some of which are potentially remediable.
AB - Risk factors for vertebral fractures due to osteoporosis were evaluated in 105 consecutive male patients over a four-year period. An equal number of men with Paget's disease, matched by age, who concurrently attended the same subspecialty clinic served as control subjects. The relative risk for osteoporosis, estimated by the odds ratio, was increased among those who smoke cigarettes (relative risk = 2.3; p = 0.01), drank alcoholic beverages (relative risk = 2.4; p = 0.02), or had an associated medical disease known to affect calcium or bone metabolism (relative risk = 5.5; p < 0.001). Obesity was protective (relative risk = 0.3; p < 0.001). As assessed by a multiple logistic model, the risk associated with smoking and drinking increased with age. The effects of these four major risk factors were largely independent of one another and were cumulative. Thus, spinal osteoporosis in men is frequently associated with recognizable risk factors, some of which are potentially remediable.
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U2 - 10.1016/0002-9343(83)90878-1
DO - 10.1016/0002-9343(83)90878-1
M3 - Article
C2 - 6650552
AN - SCOPUS:0021049966
SN - 0002-9343
VL - 75
SP - 977
EP - 983
JO - The American Journal of Medicine
JF - The American Journal of Medicine
IS - 6
ER -