Risk factors for prosthetic joint infection: Case-control study

Elie F. Berbari, Arlen D. Hanssen, Mary C. Duffy, James M. Steckelberg, Duane M. Ilstrup, William S. Harmsen, Douglas R. Osmon

Research output: Contribution to journalArticle

577 Scopus citations

Abstract

We conducted a matched case-control study to determine risk factors for the development of prosthetic joint infection. Cases were patients with prosthetic hip or knee joint infection. Controls were patients who underwent total hip or knee arthroplasty and did not develop prosthetic joint infection. A multiple logistic regression model indicated that risk factors for prosthetic joint infection were the development of a surgical site infection not involving the prosthesis (odds ratio [OR], 35.9; 95% confidence interval [CI], 8.3-154.6), a National Nosocomial Infections Surveillance (NNIS) System surgical patient risk index score of 1 (OR, 1.7; 95% CI, 1.2- 2.3) or 2 (OR, 3.9; 95% CI, 2.0-7.5), the presence of a malignancy (OR, 3.1; 95% CI, 1.3-7.2), and a history of joint arthroplasty (OR, 2.0; 95% CI, 1.4- 3.0). Our findings suggest that a surgical site infection not involving the joint prosthesis, an NNIS System surgical patient risk index score of 1 or 2, the presence of a malignancy, and a history of a joint arthroplasty are associated with an increased risk of prosthetic joint infection.

Original languageEnglish (US)
Pages (from-to)1247-1254
Number of pages8
JournalClinical Infectious Diseases
Volume27
Issue number5
DOIs
StatePublished - Nov 1998

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Berbari, E. F., Hanssen, A. D., Duffy, M. C., Steckelberg, J. M., Ilstrup, D. M., Harmsen, W. S., & Osmon, D. R. (1998). Risk factors for prosthetic joint infection: Case-control study. Clinical Infectious Diseases, 27(5), 1247-1254. https://doi.org/10.1086/514991