Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study

Harindra Jayasekara, Jeanette C. Reece, Daniel D. Buchanan, Christophe Rosty, S. Ghazaleh Dashti, Driss Ait Ouakrim, Ingrid M. Winship, Finlay A. Macrae, Alex Boussioutas, Graham G. Giles, Dennis J. Ahnen, Jan Lowery, Graham Casey, Robert W. Haile, Steven Gallinger, Loic Le Marchand, Polly A. Newcomb, Noralane Morey Lindor, John L. Hopper, Susan ParryMark A. Jenkins, Aung Ko Win

Research output: Contribution to journalArticle

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Abstract

Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour-related and lifestyle risk factors, and risk of metachronous CRC. A total of 7,863 participants with incident colon or rectal cancer who were recruited in the USA, Canada and Australia to the Colon Cancer Family Registry during 1997-2012, except those identified as high-risk, for example, Lynch syndrome, were followed up approximately every 5 years. We estimated the risk of metachronous CRC, defined as the first new primary CRC following an interval of at least one year after the initial CRC diagnosis. Observation time started at the age at diagnosis of the initial CRC and ended at the age at diagnosis of the metachronous CRC, last contact or death whichever occurred earliest, or were censored at the age at diagnosis of any metachronous colorectal adenoma. Cox regression was used to derive hazard ratios (HRs) and 95% confidence intervals (CIs). During a mean follow-up of 6.6 years, 142 (1.81%) metachronous CRCs were diagnosed (mean age at diagnosis 59.8; incidence 2.7/1,000 person-years). An increased risk of metachronous CRC was associated with the presence of a synchronous CRC (HR=2.73; 95% CI: 1.30-5.72) and the location of cancer in the proximal colon at initial diagnosis (compared with distal colon or rectum, HR=4.16; 95% CI: 2.80-6.18). The presence of a synchronous CRC and the location of the initial CRC might be useful for deciding the intensity of surveillance colonoscopy for individuals diagnosed with CRC.

Original languageEnglish (US)
JournalInternational Journal of Cancer
DOIs
StateAccepted/In press - 2016

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Colorectal Neoplasms
Cohort Studies
Prospective Studies
Confidence Intervals
Colonic Neoplasms
Colon
Hereditary Nonpolyposis Colorectal Neoplasms
Colonoscopy
Rectal Neoplasms
Rectum
Adenoma
Canada
Registries
Life Style
Neoplasms
Observation
Incidence

Keywords

  • Colorectal cancer
  • Metachronous
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Jayasekara, H., Reece, J. C., Buchanan, D. D., Rosty, C., Dashti, S. G., Ait Ouakrim, D., ... Win, A. K. (Accepted/In press). Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study. International Journal of Cancer. https://doi.org/10.1002/ijc.30153

Risk factors for metachronous colorectal cancer following a primary colorectal cancer : A prospective cohort study. / Jayasekara, Harindra; Reece, Jeanette C.; Buchanan, Daniel D.; Rosty, Christophe; Dashti, S. Ghazaleh; Ait Ouakrim, Driss; Winship, Ingrid M.; Macrae, Finlay A.; Boussioutas, Alex; Giles, Graham G.; Ahnen, Dennis J.; Lowery, Jan; Casey, Graham; Haile, Robert W.; Gallinger, Steven; Le Marchand, Loic; Newcomb, Polly A.; Lindor, Noralane Morey; Hopper, John L.; Parry, Susan; Jenkins, Mark A.; Win, Aung Ko.

In: International Journal of Cancer, 2016.

Research output: Contribution to journalArticle

Jayasekara, H, Reece, JC, Buchanan, DD, Rosty, C, Dashti, SG, Ait Ouakrim, D, Winship, IM, Macrae, FA, Boussioutas, A, Giles, GG, Ahnen, DJ, Lowery, J, Casey, G, Haile, RW, Gallinger, S, Le Marchand, L, Newcomb, PA, Lindor, NM, Hopper, JL, Parry, S, Jenkins, MA & Win, AK 2016, 'Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study', International Journal of Cancer. https://doi.org/10.1002/ijc.30153
Jayasekara, Harindra ; Reece, Jeanette C. ; Buchanan, Daniel D. ; Rosty, Christophe ; Dashti, S. Ghazaleh ; Ait Ouakrim, Driss ; Winship, Ingrid M. ; Macrae, Finlay A. ; Boussioutas, Alex ; Giles, Graham G. ; Ahnen, Dennis J. ; Lowery, Jan ; Casey, Graham ; Haile, Robert W. ; Gallinger, Steven ; Le Marchand, Loic ; Newcomb, Polly A. ; Lindor, Noralane Morey ; Hopper, John L. ; Parry, Susan ; Jenkins, Mark A. ; Win, Aung Ko. / Risk factors for metachronous colorectal cancer following a primary colorectal cancer : A prospective cohort study. In: International Journal of Cancer. 2016.
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abstract = "Individuals diagnosed with colorectal cancer (CRC) are at risk of developing a metachronous CRC. We examined the associations between personal, tumour-related and lifestyle risk factors, and risk of metachronous CRC. A total of 7,863 participants with incident colon or rectal cancer who were recruited in the USA, Canada and Australia to the Colon Cancer Family Registry during 1997-2012, except those identified as high-risk, for example, Lynch syndrome, were followed up approximately every 5 years. We estimated the risk of metachronous CRC, defined as the first new primary CRC following an interval of at least one year after the initial CRC diagnosis. Observation time started at the age at diagnosis of the initial CRC and ended at the age at diagnosis of the metachronous CRC, last contact or death whichever occurred earliest, or were censored at the age at diagnosis of any metachronous colorectal adenoma. Cox regression was used to derive hazard ratios (HRs) and 95{\%} confidence intervals (CIs). During a mean follow-up of 6.6 years, 142 (1.81{\%}) metachronous CRCs were diagnosed (mean age at diagnosis 59.8; incidence 2.7/1,000 person-years). An increased risk of metachronous CRC was associated with the presence of a synchronous CRC (HR=2.73; 95{\%} CI: 1.30-5.72) and the location of cancer in the proximal colon at initial diagnosis (compared with distal colon or rectum, HR=4.16; 95{\%} CI: 2.80-6.18). The presence of a synchronous CRC and the location of the initial CRC might be useful for deciding the intensity of surveillance colonoscopy for individuals diagnosed with CRC.",
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