Risk factors for low bone mass-related fractures in men

A systematic review and meta-analysis

Matthew M Drake, Mohammad H Murad, Karen F. Mauck, Melanie A. Lane, Chaitanya Undavalli, Tarig Elraiyah, Louise M. Stuart, Chaithra Prasad, Anas Shahrour, Rebecca J. Mullan, Ahmad Hazem, Patricia J. Erwin, Victor Manuel Montori

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Context: Testing men at increased risk for osteoporotic fractures has been recommended. Objective: The aim of this study was to estimate the magnitude of association and quality of supporting evidence linking multiple risk factors with low bone mass-related fractures in men. Data Sources: We searched MEDLINE, EMBASE, Web of Science, SCOPUS and Cochrane CENTRAL through February 2010. We identified further studies by reviewing reference lists from selected studies and reviews. Study Selection: Eligible studies had to enroll men and quantitatively evaluate the association of risk factors with low bone density-related fractures. Data Extraction: Reviewers working independently and in duplicate determined study eligibility and extracted study description, quality, and outcome data. Data Synthesis: Fifty-five studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate with fair levels of multivariable adjustment and adequate exposure and outcome ascertainment. Statistically significant associations were established for age, low body mass index, current smoking, excessive alcohol use, chronic corticosteroid use, history of prior fractures, history of falls, history of hypogonadism, history of stroke, and history of diabetes. Statistical heterogeneity of the meta-analytic estimates of all associations was significant except for chronic corticosteroid use. None of these associations were of large magnitude (i.e. adjusted odds ratios were generally <2). No evidence supporting a particular effective testing or screening strategy was identified. Conclusions: Multiple risk factors for fractures in men were identified, but their usefulness for stratifying and selecting men for bone density testing remains uncertain.

Original languageEnglish (US)
Pages (from-to)1861-1870
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number6
DOIs
StatePublished - Jun 2012

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Meta-Analysis
Bone
Bone and Bones
Bone Density
Adrenal Cortex Hormones
Testing
Association reactions
Social Adjustment
Osteoporotic Fractures
Hypogonadism
Information Storage and Retrieval
Medical problems
MEDLINE
Observational Studies
Screening
Body Mass Index
Smoking
Stroke
Odds Ratio
Alcohols

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Risk factors for low bone mass-related fractures in men : A systematic review and meta-analysis. / Drake, Matthew M; Murad, Mohammad H; Mauck, Karen F.; Lane, Melanie A.; Undavalli, Chaitanya; Elraiyah, Tarig; Stuart, Louise M.; Prasad, Chaithra; Shahrour, Anas; Mullan, Rebecca J.; Hazem, Ahmad; Erwin, Patricia J.; Montori, Victor Manuel.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 97, No. 6, 06.2012, p. 1861-1870.

Research output: Contribution to journalArticle

Drake, MM, Murad, MH, Mauck, KF, Lane, MA, Undavalli, C, Elraiyah, T, Stuart, LM, Prasad, C, Shahrour, A, Mullan, RJ, Hazem, A, Erwin, PJ & Montori, VM 2012, 'Risk factors for low bone mass-related fractures in men: A systematic review and meta-analysis', Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 6, pp. 1861-1870. https://doi.org/10.1210/jc.2011-3058
Drake, Matthew M ; Murad, Mohammad H ; Mauck, Karen F. ; Lane, Melanie A. ; Undavalli, Chaitanya ; Elraiyah, Tarig ; Stuart, Louise M. ; Prasad, Chaithra ; Shahrour, Anas ; Mullan, Rebecca J. ; Hazem, Ahmad ; Erwin, Patricia J. ; Montori, Victor Manuel. / Risk factors for low bone mass-related fractures in men : A systematic review and meta-analysis. In: Journal of Clinical Endocrinology and Metabolism. 2012 ; Vol. 97, No. 6. pp. 1861-1870.
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