Risk factors for locoregional relapse after transoral robotic surgery for human papillomavirus-related oropharyngeal squamous cell carcinoma

Ryan K. Funk, Eric J. Moore, Joaquín J. García, W. Scott Harmsen, David G. Stoddard, Eneida F. Vencio, Robert L. Foote, Katharine A. Price, Daniel J. Ma

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Background: Factors predicting locoregional relapse after surgery for oropharyngeal squamous cell carcinoma (SCC) were identified in the pre-human papillomavirus (HPV) era. We examined whether traditional indications for adjuvant radiotherapy (RT) or adjuvant chemoradiotherapy (CRT) still correlate with locoregional relapse in HPV-positive patients after transoral robotic surgery (TORS). Methods: Retrospective review of oropharyngeal SCC cases identified patients with HPV-positive tumors who did not receive adjuvant therapy after TORS despite intermediate or high-risk features. Results: Median follow-up was 26.7 months (range, 4.9-73.1 months). Five of 25 eligible patients (20%) relapsed at a median 4.8 months (range, 3.2-7.8 months). Two of 18 (11%) intermediate and 3 of 7 (43%) high-risk patients relapsed. Kaplan-Meier 2-year locoregional relapse-free survival estimates for intermediate and high-risk patients were 88% and 57% (p=.078), respectively. Conclusion: Traditional indications for adjuvant RT or CRT were associated with high risk of locoregional relapse in HPV-positive patients treated with TORS alone.

Original languageEnglish (US)
JournalHead and Neck
DOIs
StateAccepted/In press - 2015

Keywords

  • Adjuvant therapy
  • Human papillomavirus (HPV)
  • Oropharyngeal squamous cell carcinoma
  • Risk factors
  • Transoral robotic surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Funk, R. K., Moore, E. J., García, J. J., Harmsen, W. S., Stoddard, D. G., Vencio, E. F., Foote, R. L., Price, K. A., & Ma, D. J. (Accepted/In press). Risk factors for locoregional relapse after transoral robotic surgery for human papillomavirus-related oropharyngeal squamous cell carcinoma. Head and Neck. https://doi.org/10.1002/hed.24298