Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis

Robert R Mc Williams, Patrick Maisonneuve, William R. Bamlet, Gloria M Petersen, Donghui Li, Harvey A. Risch, Herbert Yu, Elizabeth T H Fontham, Brian Luckett, Cristina Bosetti, Eva Negri, Carlo La Vecchia, Renato Talamini, H. Bas Bueno De Mesquita, Paige Bracci, Steven Gallinger, Rachel E. Neale, Albert B. Lowenfels

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.

Original languageEnglish (US)
Pages (from-to)311-316
Number of pages6
JournalPancreas
Volume45
Issue number2
DOIs
StatePublished - Feb 1 2016

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Keywords

  • alcohol
  • early onset
  • obesity
  • pancreatic cancer
  • smoking
  • very early onset

ASJC Scopus subject areas

  • Hepatology
  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Mc Williams, R. R., Maisonneuve, P., Bamlet, W. R., Petersen, G. M., Li, D., Risch, H. A., Yu, H., Fontham, E. T. H., Luckett, B., Bosetti, C., Negri, E., La Vecchia, C., Talamini, R., De Mesquita, H. B. B., Bracci, P., Gallinger, S., Neale, R. E., & Lowenfels, A. B. (2016). Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis. Pancreas, 45(2), 311-316. https://doi.org/10.1097/MPA.0000000000000392