TY - JOUR
T1 - Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma
T2 - A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis
AU - McWilliams, Robert R.
AU - Maisonneuve, Patrick
AU - Bamlet, William R.
AU - Petersen, Gloria M.
AU - Li, Donghui
AU - Risch, Harvey A.
AU - Yu, Herbert
AU - Fontham, Elizabeth T.H.
AU - Luckett, Brian
AU - Bosetti, Cristina
AU - Negri, Eva
AU - La Vecchia, Carlo
AU - Talamini, Renato
AU - De Mesquita, H. Bas Bueno
AU - Bracci, Paige
AU - Gallinger, Steven
AU - Neale, Rachel E.
AU - Lowenfels, Albert B.
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.
AB - Objectives While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. Methods We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years, respectively. We pooled data from 8 case-control studies, including 1954 patients with EOPC and 3278 age-and sex-matched control subjects. Logistic regression analysis was performed to identify associations with EOPC and VEOPC. Results Family history of PC, diabetes mellitus, smoking, obesity, and pancreatitis were associated with EOPC. Alcohol use equal to or greater than 26 g daily also was associated with increased risk of EOPC (odds ratio, 1.49; 95% confidence interval, 1.21-1.84), and there appeared to be a dose-and age-dependent effect of alcohol on risk. The point estimate for risk of VEOPC was an odds ratio of 2.18 (95% confidence interval, 1.17-4.09). Conclusions The established risk factors for PC, including smoking, diabetes, family history of PC, and obesity, also apply to EOPC. Alcohol intake appeared to have an age-dependent effect; the strongest association was with VEOPC.
KW - alcohol
KW - early onset
KW - obesity
KW - pancreatic cancer
KW - smoking
KW - very early onset
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U2 - 10.1097/MPA.0000000000000392
DO - 10.1097/MPA.0000000000000392
M3 - Article
C2 - 26646264
AN - SCOPUS:84955668727
SN - 0885-3177
VL - 45
SP - 311
EP - 316
JO - Pancreas
JF - Pancreas
IS - 2
ER -