Risk factors for development of acute kidney injury in critically ill patients: A systematic review and meta-analysis of observational studies

Rodrigo Cartin-Ceba, Markos Kashiouris, Maria Plataki, Daryl J Kor, Ognjen Gajic, Edward T. Casey

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background. Acute kidney injury (AKI) is a frequent complication of critically ill patients. The impact of different risk factors associated with this entity in the ICU setting is unknown. Objectives. The purpose of this research was to assess the risk factors associated with the development of AKI in critically ill patients by meta-analyses of observational studies. Data Extraction. Two reviewers independently and in duplicate used a standardized form to collect data from published reports. Authors were contacted for missing data. The Newcastle-Ottawa scale assessed study quality. Data Synthesis. Data from 31 diverse studies that enrolled 504,535 critically ill individuals from a wide variety of ICUs were included. Separate random-effects meta-analyses demonstrated a significantly increased risk of AKI with older age, diabetes, hypertension, higher baseline creatinine, heart failure, sepsis/systemic inflammatory response syndrome, use of nephrotoxic drugs, higher severity of disease scores, use of vasopressors/inotropes, high risk surgery, emergency surgery, use of intra-aortic balloon pump, and longer time in cardiopulmonary bypass pump. Conclusion. The best available evidence suggests an association of AKI with 13 different risk factors in subjects admitted to the ICU. Predictive models for identification of high risk individuals for developing AKI in all types of ICU are required.

Original languageEnglish (US)
Article number691013
JournalCritical Care Research and Practice
Volume2012
DOIs
StatePublished - 2012

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Acute Kidney Injury
Critical Illness
Observational Studies
Meta-Analysis
Systemic Inflammatory Response Syndrome
Cardiopulmonary Bypass
Creatinine
Sepsis
Emergencies
Heart Failure
Hypertension
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Risk factors for development of acute kidney injury in critically ill patients : A systematic review and meta-analysis of observational studies. / Cartin-Ceba, Rodrigo; Kashiouris, Markos; Plataki, Maria; Kor, Daryl J; Gajic, Ognjen; Casey, Edward T.

In: Critical Care Research and Practice, Vol. 2012, 691013, 2012.

Research output: Contribution to journalArticle

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