Risk factors for dementia with Lewy bodies A case-control study

Brendon P. Boot, Carolyn F. Orr, J. Eric Ahlskog, Tanis Jill Ferman, Rosebud O Roberts, Vernon S. Pankratz, Dennis W Dickson, Joseph E Parisi, Jeremiah A. Aakre, Yonas Endale Geda, David S Knopman, Ronald Carl Petersen, Bradley F Boeve

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Objective: To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods: We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort. Results: Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p , 0.0001), depression (6.0; 3.7-9.5; p , 0.0001), stroke (2.8; 1.3-6.3; p 5 0.01), a family history of Parkinson disease (PD) (4.6; 2.5-8.6; p , 0.0001), and carry APOE e4 alleles (2.2; 1.5-3.3; p , 0.0001), but less likely to have had cancer (0.44; 0.27-0.70; p 5 0.0006) or use caffeine (0.29; 0.14-0.57; p , 0.0001) with a similar trend for alcohol (0.65; 0.42-1.0; p 5 0.0501). Compared with subjects with AD, subjects with DLB were younger (72.5 vs 74.9 years, p 5 0.021) and more likely to be male (odds ratio; 95% confidence interval) (5.3; 3.3-8.5; p , 0.0001), have a history of depression (4.3; 2.4-7.5; p , 0.0001), be more educated (2.5; 1.1-5.6; p 5 0.031), have a positive family history of PD (5.0; 2.4-10; p , 0.0001), have no APOE e4 alleles (0.61; 0.40-0.93; p 5 0.02), and to have had an oophorectomy before age 45 years (7.6; 1.5-39; p 5 0.015). Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either.

Original languageEnglish (US)
Pages (from-to)833-840
Number of pages8
JournalNeurology
Volume81
Issue number9
DOIs
StatePublished - Aug 27 2013

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Lewy Body Disease
Case-Control Studies
Parkinson Disease
Alzheimer Disease
Depression
Caffeine
Alleles
Odds Ratio
Confidence Intervals
Ovariectomy
Dementia
Risk Factors
Cohort Studies
Anxiety
Smoking
Stroke
Alcohols
Alzheimer's Disease
Parkinson's Disease
Education

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Boot, B. P., Orr, C. F., Ahlskog, J. E., Ferman, T. J., Roberts, R. O., Pankratz, V. S., ... Boeve, B. F. (2013). Risk factors for dementia with Lewy bodies A case-control study. Neurology, 81(9), 833-840. https://doi.org/10.1212/WNL.0b013e3182a2cbd1

Risk factors for dementia with Lewy bodies A case-control study. / Boot, Brendon P.; Orr, Carolyn F.; Ahlskog, J. Eric; Ferman, Tanis Jill; Roberts, Rosebud O; Pankratz, Vernon S.; Dickson, Dennis W; Parisi, Joseph E; Aakre, Jeremiah A.; Geda, Yonas Endale; Knopman, David S; Petersen, Ronald Carl; Boeve, Bradley F.

In: Neurology, Vol. 81, No. 9, 27.08.2013, p. 833-840.

Research output: Contribution to journalArticle

Boot BP, Orr CF, Ahlskog JE, Ferman TJ, Roberts RO, Pankratz VS et al. Risk factors for dementia with Lewy bodies A case-control study. Neurology. 2013 Aug 27;81(9):833-840. https://doi.org/10.1212/WNL.0b013e3182a2cbd1
Boot, Brendon P. ; Orr, Carolyn F. ; Ahlskog, J. Eric ; Ferman, Tanis Jill ; Roberts, Rosebud O ; Pankratz, Vernon S. ; Dickson, Dennis W ; Parisi, Joseph E ; Aakre, Jeremiah A. ; Geda, Yonas Endale ; Knopman, David S ; Petersen, Ronald Carl ; Boeve, Bradley F. / Risk factors for dementia with Lewy bodies A case-control study. In: Neurology. 2013 ; Vol. 81, No. 9. pp. 833-840.
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abstract = "Objective: To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods: We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort. Results: Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95{\%} confidence interval) (7.4; 3.5-16; p , 0.0001), depression (6.0; 3.7-9.5; p , 0.0001), stroke (2.8; 1.3-6.3; p 5 0.01), a family history of Parkinson disease (PD) (4.6; 2.5-8.6; p , 0.0001), and carry APOE e4 alleles (2.2; 1.5-3.3; p , 0.0001), but less likely to have had cancer (0.44; 0.27-0.70; p 5 0.0006) or use caffeine (0.29; 0.14-0.57; p , 0.0001) with a similar trend for alcohol (0.65; 0.42-1.0; p 5 0.0501). Compared with subjects with AD, subjects with DLB were younger (72.5 vs 74.9 years, p 5 0.021) and more likely to be male (odds ratio; 95{\%} confidence interval) (5.3; 3.3-8.5; p , 0.0001), have a history of depression (4.3; 2.4-7.5; p , 0.0001), be more educated (2.5; 1.1-5.6; p 5 0.031), have a positive family history of PD (5.0; 2.4-10; p , 0.0001), have no APOE e4 alleles (0.61; 0.40-0.93; p 5 0.02), and to have had an oophorectomy before age 45 years (7.6; 1.5-39; p 5 0.015). Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either.",
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AU - Boot, Brendon P.

AU - Orr, Carolyn F.

AU - Ahlskog, J. Eric

AU - Ferman, Tanis Jill

AU - Roberts, Rosebud O

AU - Pankratz, Vernon S.

AU - Dickson, Dennis W

AU - Parisi, Joseph E

AU - Aakre, Jeremiah A.

AU - Geda, Yonas Endale

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Boeve, Bradley F

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N2 - Objective: To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods: We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort. Results: Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p , 0.0001), depression (6.0; 3.7-9.5; p , 0.0001), stroke (2.8; 1.3-6.3; p 5 0.01), a family history of Parkinson disease (PD) (4.6; 2.5-8.6; p , 0.0001), and carry APOE e4 alleles (2.2; 1.5-3.3; p , 0.0001), but less likely to have had cancer (0.44; 0.27-0.70; p 5 0.0006) or use caffeine (0.29; 0.14-0.57; p , 0.0001) with a similar trend for alcohol (0.65; 0.42-1.0; p 5 0.0501). Compared with subjects with AD, subjects with DLB were younger (72.5 vs 74.9 years, p 5 0.021) and more likely to be male (odds ratio; 95% confidence interval) (5.3; 3.3-8.5; p , 0.0001), have a history of depression (4.3; 2.4-7.5; p , 0.0001), be more educated (2.5; 1.1-5.6; p 5 0.031), have a positive family history of PD (5.0; 2.4-10; p , 0.0001), have no APOE e4 alleles (0.61; 0.40-0.93; p 5 0.02), and to have had an oophorectomy before age 45 years (7.6; 1.5-39; p 5 0.015). Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either.

AB - Objective: To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods: We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort. Results: Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5-16; p , 0.0001), depression (6.0; 3.7-9.5; p , 0.0001), stroke (2.8; 1.3-6.3; p 5 0.01), a family history of Parkinson disease (PD) (4.6; 2.5-8.6; p , 0.0001), and carry APOE e4 alleles (2.2; 1.5-3.3; p , 0.0001), but less likely to have had cancer (0.44; 0.27-0.70; p 5 0.0006) or use caffeine (0.29; 0.14-0.57; p , 0.0001) with a similar trend for alcohol (0.65; 0.42-1.0; p 5 0.0501). Compared with subjects with AD, subjects with DLB were younger (72.5 vs 74.9 years, p 5 0.021) and more likely to be male (odds ratio; 95% confidence interval) (5.3; 3.3-8.5; p , 0.0001), have a history of depression (4.3; 2.4-7.5; p , 0.0001), be more educated (2.5; 1.1-5.6; p 5 0.031), have a positive family history of PD (5.0; 2.4-10; p , 0.0001), have no APOE e4 alleles (0.61; 0.40-0.93; p 5 0.02), and to have had an oophorectomy before age 45 years (7.6; 1.5-39; p 5 0.015). Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either.

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