Abstract
Background: The risk factors for development of viremia in high-risk donor cytomegalovirus (CMV)-seropositive and recipient CMV-seronegative (D+R-) transplant recipients are incompletely defined. Methods: The study population comprised patients in the preemptive therapy (PET) arm of a randomized, controlled trial of PET versus prophylaxis using valganciclovir in D+R- liver transplant recipients. Weekly surveillance monitoring for viremia for 100 days was performed using a sensitive CMV-DNA polymerase chain reaction assays. Risk factors for viremia and time to onset (≤4 vs >4 weeks) of viremia were examined using logistic regression models. Results: Viremia developed in 84% (79/94) of recipients and older donor age was the only independent factor associated with viremia (odds ratio, 2.20 for each quartile increase in donor age; 95% confidence interval [CI], 1.07-4.52; Pâ...=â....031). Recipients who developed early-onset viremia (within 4 weeks) also had significantly older donors than those with later-onset viremia (difference in age 10.1 years; 95% CI, 2-19; Pâ...=â....03). Conclusions: Older donor age was an independent predictor of viremia and earlier-onset of viremia in D+R- liver transplant recipients. Future studies should assess the mechanistic links underlying this novel association. Clinical Trial Registration: NCT01552369.
Original language | English (US) |
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Pages (from-to) | 1073-1077 |
Number of pages | 5 |
Journal | Journal of Infectious Diseases |
Volume | 223 |
Issue number | 6 |
DOIs | |
State | Published - Mar 15 2021 |
Keywords
- cytomegalovirus
- primary CMV infection
- transplant
- viremia
ASJC Scopus subject areas
- General Medicine