TY - JOUR
T1 - Risk factors for clinically diagnosed Alzheimer's disease
T2 - A case-control study of an Italian population
AU - Amaducci, L. A.
AU - Fratiglioni, L.
AU - Rocca, W. A.
AU - Fieschi, C.
AU - Livrea, P.
AU - Pedone, D.
AU - Bracco, L.
AU - Lippi, A.
AU - Gandolfo, C.
AU - Bino, G.
PY - 1986
Y1 - 1986
N2 - We conducted a case-control study of 116 patients with the clinical diagnosis of Alzheimer's disease (AD) in seven Italian centers. One hundred sixteen hospital controls and 97 population controls were matched by age, sex, and region of residence to the cases. A structured questionnaire was administered to the next-of-kin of cases and controls by trained interviewers to identify possible risk factors. Genetic, viral, toxic, immunologic, medical, surgical, and personality factors were investigated. Dementia among first- or second-degree relatives and advanced age of the mother at subject's birth (age over 40) were associated with AD. Head trauma was more frequent in cases than in either hospital or population controls, but the differences were not significant. Our data did not confirm the previously reported association with antecedent thyroid disease or family history of Down's syndrome.
AB - We conducted a case-control study of 116 patients with the clinical diagnosis of Alzheimer's disease (AD) in seven Italian centers. One hundred sixteen hospital controls and 97 population controls were matched by age, sex, and region of residence to the cases. A structured questionnaire was administered to the next-of-kin of cases and controls by trained interviewers to identify possible risk factors. Genetic, viral, toxic, immunologic, medical, surgical, and personality factors were investigated. Dementia among first- or second-degree relatives and advanced age of the mother at subject's birth (age over 40) were associated with AD. Head trauma was more frequent in cases than in either hospital or population controls, but the differences were not significant. Our data did not confirm the previously reported association with antecedent thyroid disease or family history of Down's syndrome.
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U2 - 10.1212/wnl.36.7.922
DO - 10.1212/wnl.36.7.922
M3 - Article
C2 - 3714054
AN - SCOPUS:0022641115
SN - 0028-3878
VL - 36
SP - 922
EP - 931
JO - Neurology
JF - Neurology
IS - 7
ER -