Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population

L. A. Amaducci, L. Fratiglioni, W. A. Rocca, C. Fieschi, P. Livrea, D. Pedone, L. Bracco, A. Lippi, C. Gandolfo, G. Bino

Research output: Contribution to journalArticle

323 Scopus citations

Abstract

We conducted a case-control study of 116 patients with the clinical diagnosis of Alzheimer's disease (AD) in seven Italian centers. One hundred sixteen hospital controls and 97 population controls were matched by age, sex, and region of residence to the cases. A structured questionnaire was administered to the next-of-kin of cases and controls by trained interviewers to identify possible risk factors. Genetic, viral, toxic, immunologic, medical, surgical, and personality factors were investigated. Dementia among first- or second-degree relatives and advanced age of the mother at subject's birth (age over 40) were associated with AD. Head trauma was more frequent in cases than in either hospital or population controls, but the differences were not significant. Our data did not confirm the previously reported association with antecedent thyroid disease or family history of Down's syndrome.

Original languageEnglish (US)
Pages (from-to)922-931
Number of pages10
JournalNeurology
Volume36
Issue number7
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population'. Together they form a unique fingerprint.

  • Cite this

    Amaducci, L. A., Fratiglioni, L., Rocca, W. A., Fieschi, C., Livrea, P., Pedone, D., Bracco, L., Lippi, A., Gandolfo, C., & Bino, G. (1986). Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population. Neurology, 36(7), 922-931. https://doi.org/10.1212/wnl.36.7.922