TY - JOUR
T1 - Risk factors for arterial and venous thrombosis in WHO-defined essential thrombocythemia
T2 - An international study of 891 patients
AU - Carobbio, Alessandra
AU - Thiele, Juergen
AU - Passamonti, Francesco
AU - Rumi, Elisa
AU - Ruggeri, Marco
AU - Rodeghiero, Francesco
AU - Randi, Maria Luigia
AU - Bertozzi, Irene
AU - Vannucchi, Alessandro M.
AU - Antonioli, Elisabetta
AU - Gisslinger, Heinz
AU - Buxhofer-Ausch, Veronika
AU - Finazzi, Guido
AU - Gangat, Naseema
AU - Tefferi, Ayalew
AU - Barbui, Tiziano
PY - 2011/6/2
Y1 - 2011/6/2
N2 - In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable analysis, predictors of arterial thrombosis included age more than 60 years (P = .03; hazard ratio [HR] = 1.7), thrombosis history (P = .003; HR = 2.1), cardiovascular risk factors including tobacco use, hypertension, or diabetes mellitus (P = .007; HR = 1.9), leukocytosis (> 11 × 10 9/L; P = .04; HR = 1.7), and presence of JAK2V617F (P = .009; HR = 2.6). In contrast, only male gender predicted venous thrombosis. Platelet count more than 1000 × 109/L was associated with a lower risk of arterial thrombosis (P = .007; HR = 0.4). These associations, except the one with leukocytosis, remained significant (or near significant) when analysis was restricted to JAK2V617F-positive cases. The current study clarifies the contribution of specific disease and host characteristics to the risk of arterial versus venous thrombosis in essential thrombocythemia.
AB - In an international collaborative study, a central histologic review identified 891 patients with essential thrombocythemia, strictly defined by World Health Organization criteria. After a median follow-up of 6.2 years, 109 (12%) patients experienced arterial (n = 79) or venous (n = 37) thrombosis. In multivariable analysis, predictors of arterial thrombosis included age more than 60 years (P = .03; hazard ratio [HR] = 1.7), thrombosis history (P = .003; HR = 2.1), cardiovascular risk factors including tobacco use, hypertension, or diabetes mellitus (P = .007; HR = 1.9), leukocytosis (> 11 × 10 9/L; P = .04; HR = 1.7), and presence of JAK2V617F (P = .009; HR = 2.6). In contrast, only male gender predicted venous thrombosis. Platelet count more than 1000 × 109/L was associated with a lower risk of arterial thrombosis (P = .007; HR = 0.4). These associations, except the one with leukocytosis, remained significant (or near significant) when analysis was restricted to JAK2V617F-positive cases. The current study clarifies the contribution of specific disease and host characteristics to the risk of arterial versus venous thrombosis in essential thrombocythemia.
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U2 - 10.1182/blood-2011-02-339002
DO - 10.1182/blood-2011-02-339002
M3 - Article
C2 - 21490340
AN - SCOPUS:79957975519
SN - 0006-4971
VL - 117
SP - 5857
EP - 5859
JO - Blood
JF - Blood
IS - 22
ER -