RIP1 comes back to life as a cell death regulator in TNFR1 signaling

Marie Anne O'Donnell, Adrian T. Ting

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Cell death induction by tumor necrosis factor has been an intensively studied area for the last two decades. Although it may appear that the skeleton should have been picked clean by now, new secrets about tumor necrosis factor death signaling are still being uncovered. In particular, the recent evidence that ubiquitination of the death kinase receptor-interacting protein 1 regulates its participation in apoptotic and necrotic cell death is opening up unexplored avenues in the catacombs of tumor necrosis factor death signaling. In this minireview, we focus on two major cell-death checkpoints that determine whether receptor-interacting protein 1 functions as a pro-survival or pro-death molecule.

Original languageEnglish (US)
Pages (from-to)877-887
Number of pages11
JournalFEBS Journal
Volume278
Issue number6
DOIs
StatePublished - Apr 2011

Keywords

  • IAP
  • NEMO
  • NF-κB
  • RIP
  • TNF
  • TRAF
  • apoptosis
  • caspase
  • necrosis
  • ubiquitin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'RIP1 comes back to life as a cell death regulator in TNFR1 signaling'. Together they form a unique fingerprint.

Cite this