Right ventricular function with hypoxic exercise: Effects of sildenafil

Jesper Kjaergaard, Eric M. Snyder, Christian Hassager, Thomas P Olson, Jae Kuen Oh, Bruce David Johnson, Robert Frantz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The effect of sildenafil on right ventricular contractility in hypoxic exercise is unknown, whereas reports have shown that sildenafil is associated with a smaller increase in pulmonary vascular resistance and right ventricular systolic pressure (RVSP) with exercise at high altitude. The present study evaluates the changes induced by controlled hypoxia on right ventricular pressure and performance with and without sildenafil administration. Tricuspid annular isovolumic acceleration (IVA) and annular velocities were measured in 14 healthy subjects at rest and after maximal exercise in a cross-over, double blind placebo controlled trial in three situations: normoxia, normobaric hypoxia with, and normobaric hypoxia without the administration of 100 mg sildenafil. RVSP, assessed by Doppler echocardiography, was determined from the peak tricuspid regurgitation pressure gradient. RVSP during rest increased from 26.9 ± 2.3 mmHg in normoxia to 37.8 ± 6.9 mmHg in hypoxia, p < 0.01; sildenafil administration reduced RVSP in hypoxia to 30.5 ± 5.6, p < 0.01. Compared to normoxia at rest, IVA increased similarly with peak exercise in normoxia and hypoxiasildenafil (by 2.37 and 1.90 m/s2, respectively), but the observed increase in IVA during exercise was smaller (0.86 m/s2, p < 0.05) in hypoxiaplacebo. Right ventricular contractility, as estimated by IVA at peak exercise is increased with the administration of sildenafil as compared to placebo, and is not different from the values seen during exercise in normoxia. This effect seems independent of the effect of sildenafil on RVSP.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalEuropean Journal of Applied Physiology
Volume102
Issue number1
DOIs
StatePublished - Dec 2007

Fingerprint

Right Ventricular Function
Ventricular Pressure
Exercise
Blood Pressure
Placebos
Tricuspid Valve Insufficiency
Doppler Echocardiography
Sildenafil Citrate
Vascular Resistance
Healthy Volunteers
Hypoxia
Pressure

Keywords

  • Hypoxia
  • Phosphodiesterase-5 inhibition
  • Pulmonary hypertension
  • Right ventricular function
  • Sildenafil

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Right ventricular function with hypoxic exercise : Effects of sildenafil. / Kjaergaard, Jesper; Snyder, Eric M.; Hassager, Christian; Olson, Thomas P; Oh, Jae Kuen; Johnson, Bruce David; Frantz, Robert.

In: European Journal of Applied Physiology, Vol. 102, No. 1, 12.2007, p. 87-95.

Research output: Contribution to journalArticle

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