Right ventricular free wall circumferential strain reflects graded elevation in acute right ventricular afterload

Eun Joo Cho, Panupong Jiamsripong, Anna M. Calleja, Mohsen S. Alharthi, Eileen M. McMahon, Bijoy K. Khandheria, Marek Belohlavek

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

This study was designed to evaluate the concurrent changes in the right ventricular free wall (RVFW) movement in experimentally induced, acute mild, moderate, and severe right ventricle (RV) afterload conditions. In 14 open-chest pigs (weight 43 ± 4 kg) with preserved pericardia, acute mild (>35 and <50 mmHg), moderate (>50 and <60 mmHg), and severe (>60 mmHg) increases in RV systolic pressure (RVSP) were induced by constriction of the pulmonary artery. At each step, longitudinal, radial, and circumferential strains and strain rates were measured in both the RVFW and the interven- tricular septum. The mean RVSPs were 31.0 ± 4.3 mmHg at baseline and 41.1 ± 2.7 mmHg during mild, 52.7 ± 3.4 mmHg during moderate, and 61.7 ± 1.6 mmHg during severe afterload conditions. The RVFW circumferential strains showed significant differences among baseline, mild, moderate, and severe afterload conditions (-10.5 ± 3.9, -8.3 ± 3.3, -5.4 ± 2.7, and -7.5 ± 5.3%, respectively, P = 0.008) and had significant linear correlation with RVSP (r = 0.636, P < 0.001) if the severe condition was excluded. Decrease of the RVFW circumferential strain magnitude is the most distinct response in acute mild and moderate RV afterload that could aid in detection of clinical conditions associated with acutely increasing RV afterload.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume296
Issue number2
DOIs
StatePublished - Feb 2009

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Heart Ventricles
Blood Pressure
Pericardium
Constriction
Pulmonary Artery
Swine
Thorax
Weights and Measures

Keywords

  • Afterload
  • Right ventricle
  • Strain echocardiography

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Right ventricular free wall circumferential strain reflects graded elevation in acute right ventricular afterload. / Cho, Eun Joo; Jiamsripong, Panupong; Calleja, Anna M.; Alharthi, Mohsen S.; McMahon, Eileen M.; Khandheria, Bijoy K.; Belohlavek, Marek.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 296, No. 2, 02.2009.

Research output: Contribution to journalArticle

Cho, Eun Joo ; Jiamsripong, Panupong ; Calleja, Anna M. ; Alharthi, Mohsen S. ; McMahon, Eileen M. ; Khandheria, Bijoy K. ; Belohlavek, Marek. / Right ventricular free wall circumferential strain reflects graded elevation in acute right ventricular afterload. In: American Journal of Physiology - Heart and Circulatory Physiology. 2009 ; Vol. 296, No. 2.
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