Right place, right time, and only once: Replication initiation in metazoans

Yuichi J. Machida, Joyce L. Hamlin, Anindya Dutta

Research output: Contribution to journalReview article

226 Scopus citations

Abstract

DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.

Original languageEnglish (US)
Pages (from-to)13-24
Number of pages12
JournalCell
Volume123
Issue number1
DOIs
StatePublished - Oct 7 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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