Right place, right time, and only once: Replication initiation in metazoans

Yuichi J. Machida, Joyce L. Hamlin, Anindya Dutta

Research output: Contribution to journalReview article

224 Scopus citations


DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.

Original languageEnglish (US)
Pages (from-to)13-24
Number of pages12
Issue number1
StatePublished - Oct 7 2005


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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