Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass

M. Dahm, S. Nikolic, D. Heublein, E. L. Yellin, John C Jr. Burnett, R. W M Frater

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Previous studies of ANF production during cardiopulmonary bypass (CPB) showed a paradoxical rise despite low (negative) RAP. We thus postulated that ANF secretion could be stimulated by inward atrial stretch (atrial inversion due to emptying of the RA by siphonage through the venous cannula, accompanied by negative RAP) or by trauma by the surgeon. To test this hypotheses RA preload was controlled by right heart bypass, and trauma to the RA was avoided by extrapericardial cannulation of SVC, IVC and PA in 7 anesthetized dogs. Blood sampling catheters and pressure micromanometers were placed in RA and aorta. Blood was collected at 42 different hemodynamic states and ANF concentration determined by radioimmunoassay. Concentration in RA ([RA]) and in aorta ([Ao]) increased with RAP within the physiological (positive) range: [RA] = 38.8*RAP-5.9, (r = 0.91, p<0.001); [Ao] = 24.7*RAP-3.0 (r = 0.93, p<0.01). The increase in concentration of ANF in the RA and in the Aorta also correlated strongly with the negative magnitude of RA pressure: [RA] = 26.9*RAP+0.1 (r = 0.83, p<0.01); [Ao] = -14.8*RAP-3.1 (r = 0.81, p<0.02). We conclude: normal right atrial pressure control of ANF secretion is abolished during CPB. The unphysiological stimulus of atrial inversion causes high right atrial ANF production. This fact may explain the sudden fall in vascular resistence with onset of CPB.

Original languageEnglish (US)
Title of host publicationEndocrine response to anesthesia and intensive care
Subtitle of host publicationproceedings of the 4th International Symposium on Endocrinology in Anesthesia and Surgery. ICS893
EditorsA. Matsuki, H. Ishihara, T. Oyama, A. Matsuki, H. Ishihara, T. Oyama
PublisherElsevier Science Publishers B.V.
Pages167-170
Number of pages4
ISBN (Print)0444812040
StatePublished - 1990
EventThe 4th International Symposium on Endocrinology in Anesthesia and Surgery -
Duration: Sep 14 1989Sep 15 1989

Other

OtherThe 4th International Symposium on Endocrinology in Anesthesia and Surgery
Period9/14/899/15/89

Fingerprint

Atrial Natriuretic Factor
Cardiopulmonary Bypass
Aorta
Right Heart Bypass
Pressure
Atrial Pressure
Wounds and Injuries
Catheterization
Radioimmunoassay
Blood Vessels
Catheters
Hemodynamics
Dogs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Dahm, M., Nikolic, S., Heublein, D., Yellin, E. L., Burnett, J. C. J., & Frater, R. W. M. (1990). Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass. In A. Matsuki, H. Ishihara, T. Oyama, A. Matsuki, H. Ishihara, & T. Oyama (Eds.), Endocrine response to anesthesia and intensive care: proceedings of the 4th International Symposium on Endocrinology in Anesthesia and Surgery. ICS893 (pp. 167-170). Elsevier Science Publishers B.V..

Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass. / Dahm, M.; Nikolic, S.; Heublein, D.; Yellin, E. L.; Burnett, John C Jr.; Frater, R. W M.

Endocrine response to anesthesia and intensive care: proceedings of the 4th International Symposium on Endocrinology in Anesthesia and Surgery. ICS893. ed. / A. Matsuki; H. Ishihara; T. Oyama; A. Matsuki; H. Ishihara; T. Oyama. Elsevier Science Publishers B.V., 1990. p. 167-170.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dahm, M, Nikolic, S, Heublein, D, Yellin, EL, Burnett, JCJ & Frater, RWM 1990, Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass. in A Matsuki, H Ishihara, T Oyama, A Matsuki, H Ishihara & T Oyama (eds), Endocrine response to anesthesia and intensive care: proceedings of the 4th International Symposium on Endocrinology in Anesthesia and Surgery. ICS893. Elsevier Science Publishers B.V., pp. 167-170, The 4th International Symposium on Endocrinology in Anesthesia and Surgery, 9/14/89.
Dahm M, Nikolic S, Heublein D, Yellin EL, Burnett JCJ, Frater RWM. Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass. In Matsuki A, Ishihara H, Oyama T, Matsuki A, Ishihara H, Oyama T, editors, Endocrine response to anesthesia and intensive care: proceedings of the 4th International Symposium on Endocrinology in Anesthesia and Surgery. ICS893. Elsevier Science Publishers B.V. 1990. p. 167-170
Dahm, M. ; Nikolic, S. ; Heublein, D. ; Yellin, E. L. ; Burnett, John C Jr. ; Frater, R. W M. / Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass. Endocrine response to anesthesia and intensive care: proceedings of the 4th International Symposium on Endocrinology in Anesthesia and Surgery. ICS893. editor / A. Matsuki ; H. Ishihara ; T. Oyama ; A. Matsuki ; H. Ishihara ; T. Oyama. Elsevier Science Publishers B.V., 1990. pp. 167-170
@inproceedings{b6c265b7a5ff49d09f1ea5dee3829d05,
title = "Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass",
abstract = "Previous studies of ANF production during cardiopulmonary bypass (CPB) showed a paradoxical rise despite low (negative) RAP. We thus postulated that ANF secretion could be stimulated by inward atrial stretch (atrial inversion due to emptying of the RA by siphonage through the venous cannula, accompanied by negative RAP) or by trauma by the surgeon. To test this hypotheses RA preload was controlled by right heart bypass, and trauma to the RA was avoided by extrapericardial cannulation of SVC, IVC and PA in 7 anesthetized dogs. Blood sampling catheters and pressure micromanometers were placed in RA and aorta. Blood was collected at 42 different hemodynamic states and ANF concentration determined by radioimmunoassay. Concentration in RA ([RA]) and in aorta ([Ao]) increased with RAP within the physiological (positive) range: [RA] = 38.8*RAP-5.9, (r = 0.91, p<0.001); [Ao] = 24.7*RAP-3.0 (r = 0.93, p<0.01). The increase in concentration of ANF in the RA and in the Aorta also correlated strongly with the negative magnitude of RA pressure: [RA] = 26.9*RAP+0.1 (r = 0.83, p<0.01); [Ao] = -14.8*RAP-3.1 (r = 0.81, p<0.02). We conclude: normal right atrial pressure control of ANF secretion is abolished during CPB. The unphysiological stimulus of atrial inversion causes high right atrial ANF production. This fact may explain the sudden fall in vascular resistence with onset of CPB.",
author = "M. Dahm and S. Nikolic and D. Heublein and Yellin, {E. L.} and Burnett, {John C Jr.} and Frater, {R. W M}",
year = "1990",
language = "English (US)",
isbn = "0444812040",
pages = "167--170",
editor = "A. Matsuki and H. Ishihara and T. Oyama and A. Matsuki and H. Ishihara and T. Oyama",
booktitle = "Endocrine response to anesthesia and intensive care",
publisher = "Elsevier Science Publishers B.V.",

}

TY - GEN

T1 - Right atrial inversion causes increased ANF secretion during cardiopulmonary bypass

AU - Dahm, M.

AU - Nikolic, S.

AU - Heublein, D.

AU - Yellin, E. L.

AU - Burnett, John C Jr.

AU - Frater, R. W M

PY - 1990

Y1 - 1990

N2 - Previous studies of ANF production during cardiopulmonary bypass (CPB) showed a paradoxical rise despite low (negative) RAP. We thus postulated that ANF secretion could be stimulated by inward atrial stretch (atrial inversion due to emptying of the RA by siphonage through the venous cannula, accompanied by negative RAP) or by trauma by the surgeon. To test this hypotheses RA preload was controlled by right heart bypass, and trauma to the RA was avoided by extrapericardial cannulation of SVC, IVC and PA in 7 anesthetized dogs. Blood sampling catheters and pressure micromanometers were placed in RA and aorta. Blood was collected at 42 different hemodynamic states and ANF concentration determined by radioimmunoassay. Concentration in RA ([RA]) and in aorta ([Ao]) increased with RAP within the physiological (positive) range: [RA] = 38.8*RAP-5.9, (r = 0.91, p<0.001); [Ao] = 24.7*RAP-3.0 (r = 0.93, p<0.01). The increase in concentration of ANF in the RA and in the Aorta also correlated strongly with the negative magnitude of RA pressure: [RA] = 26.9*RAP+0.1 (r = 0.83, p<0.01); [Ao] = -14.8*RAP-3.1 (r = 0.81, p<0.02). We conclude: normal right atrial pressure control of ANF secretion is abolished during CPB. The unphysiological stimulus of atrial inversion causes high right atrial ANF production. This fact may explain the sudden fall in vascular resistence with onset of CPB.

AB - Previous studies of ANF production during cardiopulmonary bypass (CPB) showed a paradoxical rise despite low (negative) RAP. We thus postulated that ANF secretion could be stimulated by inward atrial stretch (atrial inversion due to emptying of the RA by siphonage through the venous cannula, accompanied by negative RAP) or by trauma by the surgeon. To test this hypotheses RA preload was controlled by right heart bypass, and trauma to the RA was avoided by extrapericardial cannulation of SVC, IVC and PA in 7 anesthetized dogs. Blood sampling catheters and pressure micromanometers were placed in RA and aorta. Blood was collected at 42 different hemodynamic states and ANF concentration determined by radioimmunoassay. Concentration in RA ([RA]) and in aorta ([Ao]) increased with RAP within the physiological (positive) range: [RA] = 38.8*RAP-5.9, (r = 0.91, p<0.001); [Ao] = 24.7*RAP-3.0 (r = 0.93, p<0.01). The increase in concentration of ANF in the RA and in the Aorta also correlated strongly with the negative magnitude of RA pressure: [RA] = 26.9*RAP+0.1 (r = 0.83, p<0.01); [Ao] = -14.8*RAP-3.1 (r = 0.81, p<0.02). We conclude: normal right atrial pressure control of ANF secretion is abolished during CPB. The unphysiological stimulus of atrial inversion causes high right atrial ANF production. This fact may explain the sudden fall in vascular resistence with onset of CPB.

UR - http://www.scopus.com/inward/record.url?scp=0025047143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025047143&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0025047143

SN - 0444812040

SP - 167

EP - 170

BT - Endocrine response to anesthesia and intensive care

A2 - Matsuki, A.

A2 - Ishihara, H.

A2 - Oyama, T.

A2 - Matsuki, A.

A2 - Ishihara, H.

A2 - Oyama, T.

PB - Elsevier Science Publishers B.V.

ER -