Rheumatologic manifestations of sarcoidosis

Nadera J. Sweiss, Karen Patterson, Ray Sawaqed, Umair Jabbar, Peter Korsten, Kyle Hogarth, Robert Wollman, Joe G.N. Garcia, Timothy B. Niewold, Robert P. Baughman

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Sarcoidosis is a systemic, clinically heterogeneous disease characterized by the development of granulomas. Any organ system can be involved, and patients may present with any number of rheumatologic symptoms. There are no U.S. Food and Drug Administrationapproved therapies for the treatment of sarcoidosis. Diagnosing sarcoidosis becomes challenging, particularly when its complications cause patients symptoms to mimic other conditions, including polymyositis, Sjgren syndrome, or vasculitis. This review presents an overview of the etiology of and biomarkers associated with sarcoidosis. We then provide a detailed description of the rheumatologic manifestations of sarcoidosis and present a treatment algorithm based on current clinical evidence for patients with sarcoid arthritis. The discussion will focus on characteristic findings in patients with sarcoid arthritis, osseous involvement in sarcoidosis, and sarcoid myopathy. Arthritic conditions that sometimes coexist with sarcoidosis are described as well. We present two cases of sarcoidosis with rheumatologic manifestations. Our intent is to encourage a multidisciplinary, translational approach to meet the challenges and difficulties in understanding and treating sarcoidosis.

Original languageEnglish (US)
Pages (from-to)463-473
Number of pages11
JournalSeminars in Respiratory and Critical Care Medicine
Volume31
Issue number4
DOIs
StatePublished - 2010

Keywords

  • Sarcoidosis
  • arthritis
  • myopathy
  • rheumatic diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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    Sweiss, N. J., Patterson, K., Sawaqed, R., Jabbar, U., Korsten, P., Hogarth, K., Wollman, R., Garcia, J. G. N., Niewold, T. B., & Baughman, R. P. (2010). Rheumatologic manifestations of sarcoidosis. Seminars in Respiratory and Critical Care Medicine, 31(4), 463-473. https://doi.org/10.1055/s-0030-1262214