Rheumatic manifestations in malignancy

Mohannad A. Abu-Hilal, Eric Lawrence Matteson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The association between malignancy and rheumatic diseases is complex and many factors contribute to it. Malignancies may lead to rheumatic manifestations either directly by invasion or metastases, or indirectly by remote para-neoplastic effects. Chemotherapeutic agents and bone marrow stimulatory biologic agents such as G-CSF and GM-CSF used in the treatment of malignant diseases may also result in rheumatic symptoms. While many of these rheumatic symptoms occur during the course of the malignant disease, often these rheumatic manifestations are the initial presenting features of a hidden malignancy or sometimes occur as late complications of them. Most of the cancer associated rheumatic disorders have no distinguishing features. As well, it is generally held that an extensive search for occult malignancy, beyond routine age-appropriate cancer screening, is not cost efficient and is not recommended unless accompanied by symptoms and signs suggestive of cancer. In this review, we identify rheumatic manifestations associated with malignancy and call attention to possible features that may suggest the presence of an occult malignancy. Awareness of these features may permit earlier diagnosis of the malignancy or its relapse.

Original languageEnglish (US)
Pages (from-to)50-58
Number of pages9
JournalCurrent Rheumatology Reviews
Volume4
Issue number1
DOIs
StatePublished - Feb 2008

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Neoplasms
Granulocyte-Macrophage Colony-Stimulating Factor
Rheumatic Diseases
Biological Factors
Granulocyte Colony-Stimulating Factor
Early Detection of Cancer
Signs and Symptoms
Early Diagnosis
Bone Marrow
Neoplasm Metastasis
Costs and Cost Analysis
Recurrence

Keywords

  • Malignancy
  • Paraneoplastic syndrome
  • Rheumatic disease

ASJC Scopus subject areas

  • Rheumatology

Cite this

Rheumatic manifestations in malignancy. / Abu-Hilal, Mohannad A.; Matteson, Eric Lawrence.

In: Current Rheumatology Reviews, Vol. 4, No. 1, 02.2008, p. 50-58.

Research output: Contribution to journalArticle

Abu-Hilal, Mohannad A. ; Matteson, Eric Lawrence. / Rheumatic manifestations in malignancy. In: Current Rheumatology Reviews. 2008 ; Vol. 4, No. 1. pp. 50-58.
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