TY - JOUR
T1 - rhBMP-2 protects against reoperation for pseudoarthrosis and/or instrumentation failure
T2 - A matched case-control study of 448 patients
AU - Macki, Mohamed
AU - Syeda, Sbaa
AU - Kerezoudis, Panagiotis
AU - Bydon, Ali
AU - Witham, Timothy F.
AU - Sciubba, Daniel M.
AU - Wolinsky, Jean Paul
AU - Bydon, Mohamad
AU - Gokaslan, Ziya
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/10/1
Y1 - 2016/10/1
N2 - The objective of this independent study is to determine the impact of recombinant human bone morphogenetic protein 2 (rhBMP-2) on reoperation for pseudarthrosis and/or instrumentation failure. A nested case-control study of first-time posterolateral, instrumented fusion of the lumbar spine for degenerative spinal disease was undertaken. Cases of reoperation for pseudoarthrosis and/or instrumentation failure were assigned to controls, who did not experience the primary outcome measure at the time of reoperation. Cases and controls were matched on number of interspaces fused and inclusion of interbody. Predictors of reoperation for pseudoarthrosis and/or instrumentation failure were assessed with a conditional logistical regression controlling for rhBMP-2, age, obesity, and smoking. Of the 448 patients, 155 cases of reoperation for pseudoarthrosis and/or instrumentation were matched with 293 controls. Twenty-six percent of first-time surgeries included rhBMP-2, which was statistically more commonly used in the control cohort (33.11%) versus the case cohort (12.90%) (Unadjusted odds ratio [ORunadj] = 0.28) (95% confidence interval [CI]: 0.16–0.49). Following a multivariate analysis controlling for age, obesity, and smoking, the rhBMP-2 recipients incurred a 73% lower odds of reoperation for pseudoarthrosis and/or instrumentation failure (95% CI, 0.15–0.48). Neither sarcomatous nor osseous neoplasm was detected in the study population. Mean follow up did not differ between the cases (81.57 ± standard deviation [SD] 4.98 months) versus controls (74.75 ± 2.49 month) (ORunadj = 1.01) (95% CI: 1.00–1.01). rhBMP-2 in lumbar fusion constructs protects against reoperation for pseudoarthrosis and/or instrumentation failure. However, the decision to include fusion supplements should be weighted between surgical determinants and clinical outcomes.
AB - The objective of this independent study is to determine the impact of recombinant human bone morphogenetic protein 2 (rhBMP-2) on reoperation for pseudarthrosis and/or instrumentation failure. A nested case-control study of first-time posterolateral, instrumented fusion of the lumbar spine for degenerative spinal disease was undertaken. Cases of reoperation for pseudoarthrosis and/or instrumentation failure were assigned to controls, who did not experience the primary outcome measure at the time of reoperation. Cases and controls were matched on number of interspaces fused and inclusion of interbody. Predictors of reoperation for pseudoarthrosis and/or instrumentation failure were assessed with a conditional logistical regression controlling for rhBMP-2, age, obesity, and smoking. Of the 448 patients, 155 cases of reoperation for pseudoarthrosis and/or instrumentation were matched with 293 controls. Twenty-six percent of first-time surgeries included rhBMP-2, which was statistically more commonly used in the control cohort (33.11%) versus the case cohort (12.90%) (Unadjusted odds ratio [ORunadj] = 0.28) (95% confidence interval [CI]: 0.16–0.49). Following a multivariate analysis controlling for age, obesity, and smoking, the rhBMP-2 recipients incurred a 73% lower odds of reoperation for pseudoarthrosis and/or instrumentation failure (95% CI, 0.15–0.48). Neither sarcomatous nor osseous neoplasm was detected in the study population. Mean follow up did not differ between the cases (81.57 ± standard deviation [SD] 4.98 months) versus controls (74.75 ± 2.49 month) (ORunadj = 1.01) (95% CI: 1.00–1.01). rhBMP-2 in lumbar fusion constructs protects against reoperation for pseudoarthrosis and/or instrumentation failure. However, the decision to include fusion supplements should be weighted between surgical determinants and clinical outcomes.
KW - Bone morphogenetic protein
KW - Instrumentation failure
KW - Pseudarthosis
KW - Reoperation
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U2 - 10.1016/j.jocn.2016.03.025
DO - 10.1016/j.jocn.2016.03.025
M3 - Article
C2 - 27396376
AN - SCOPUS:84991769404
SN - 0967-5868
VL - 32
SP - 99
EP - 103
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
ER -