RFA for early esophageal neoplasia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The primary goal of endoscopic therapy for Barrett's esophagus (BE) with early esophageal neoplasia is to achieve complete eradication of the cancer and, for best long-term results, complete remission of the intestinal metaplasia (CR-IM). Radio frequency ablation (RFA) has become the mucosal ablation technique of choice, because of its improved side-effect profile and improvement in treatment efficiency. RFA is a thermal ablative modality that uses alternating electrical current to generate an electromagnetic field, which causes charged ions to rapidly oscillate and release thermal energy. Although surveillance biopsies are not included in the treatment protocol for RFA, it is proposed that failure to respond to RFA be defined by lack of improvement in the BE segment area and grade of dysplasia after two RFA sessions. Early esophageal neoplasia often presents with endoscopically visible mucosal irregularities (nodules) that can be targeted with endoscopic mucosal resection (EMR).

Original languageEnglish (US)
Title of host publicationEsophageal Cancer and Barrett's Esophagus
PublisherWiley Blackwell
Pages151-160
Number of pages10
ISBN (Electronic)9781118655153
ISBN (Print)9781118655207
DOIs
StatePublished - Dec 12 2015

Keywords

  • Barrett's esophagus
  • Endoscopic mucosal resection
  • Esophageal neoplasia
  • Radio frequency ablation
  • Subsquamous intestinal metaplasia

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Chan, D. K., Leggett, C., & Wang, K. K. N. (2015). RFA for early esophageal neoplasia. In Esophageal Cancer and Barrett's Esophagus (pp. 151-160). Wiley Blackwell. https://doi.org/10.1002/9781118655153.ch16