Revisiting the liver's role in transplant alloimmunity

Nitin Abrol, Caroline C. Jadlowiec, Timucin Taner

Research output: Contribution to journalReview article

Abstract

The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation. This phenomenon was observed nearly five decades ago. Subsequently, the liver's role in multivisceral transplantation was recognized, as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart. The liver has a unique architecture and is home to many cells involved in immunity and inflammation. After transplantation, these cells migrate from the liver into the recipient. Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system. Recent studies on human T-cell subtypes, cytokine expression, and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation. In this article, we discuss the privileged state of liver transplantation compared to other solid organ transplantation, the liver allograft's role in multivisceral transplantation, various cells in the liver involved in immune responses, and the potential mechanisms underlying immunomodulation of host alloresponses.

Original languageEnglish (US)
Pages (from-to)3123-3135
Number of pages13
JournalWorld journal of gastroenterology
Volume25
Issue number25
DOIs
StatePublished - Jan 1 2019

Fingerprint

Transplants
Liver
Immunomodulation
Allografts
Immune System
Transplantation
Transplantation Tolerance
Chimerism
Cell Transplantation
Organ Transplantation
Liver Transplantation
Immunity
Cytokines
Inflammation
T-Lymphocytes
Kidney
Gene Expression

Keywords

  • Alloimmunity
  • Liver transplantation
  • Liver-kidney transplant
  • Rejection
  • Tolerance

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Revisiting the liver's role in transplant alloimmunity. / Abrol, Nitin; Jadlowiec, Caroline C.; Taner, Timucin.

In: World journal of gastroenterology, Vol. 25, No. 25, 01.01.2019, p. 3123-3135.

Research output: Contribution to journalReview article

Abrol, Nitin ; Jadlowiec, Caroline C. ; Taner, Timucin. / Revisiting the liver's role in transplant alloimmunity. In: World journal of gastroenterology. 2019 ; Vol. 25, No. 25. pp. 3123-3135.
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