Abstract
The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation. This phenomenon was observed nearly five decades ago. Subsequently, the liver's role in multivisceral transplantation was recognized, as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart. The liver has a unique architecture and is home to many cells involved in immunity and inflammation. After transplantation, these cells migrate from the liver into the recipient. Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system. Recent studies on human T-cell subtypes, cytokine expression, and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation. In this article, we discuss the privileged state of liver transplantation compared to other solid organ transplantation, the liver allograft's role in multivisceral transplantation, various cells in the liver involved in immune responses, and the potential mechanisms underlying immunomodulation of host alloresponses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3123-3135 |
| Number of pages | 13 |
| Journal | World journal of gastroenterology |
| Volume | 25 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Alloimmunity
- Liver transplantation
- Liver-kidney transplant
- Rejection
- Tolerance
ASJC Scopus subject areas
- Gastroenterology
Cite this
Revisiting the liver's role in transplant alloimmunity. / Abrol, Nitin; Jadlowiec, Caroline C.; Taner, Timucin.
In: World journal of gastroenterology, Vol. 25, No. 25, 01.01.2019, p. 3123-3135.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Revisiting the liver's role in transplant alloimmunity
AU - Abrol, Nitin
AU - Jadlowiec, Caroline C.
AU - Taner, Timucin
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation. This phenomenon was observed nearly five decades ago. Subsequently, the liver's role in multivisceral transplantation was recognized, as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart. The liver has a unique architecture and is home to many cells involved in immunity and inflammation. After transplantation, these cells migrate from the liver into the recipient. Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system. Recent studies on human T-cell subtypes, cytokine expression, and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation. In this article, we discuss the privileged state of liver transplantation compared to other solid organ transplantation, the liver allograft's role in multivisceral transplantation, various cells in the liver involved in immune responses, and the potential mechanisms underlying immunomodulation of host alloresponses.
AB - The transplanted liver can modulate the recipient immune system to induce tolerance after transplantation. This phenomenon was observed nearly five decades ago. Subsequently, the liver's role in multivisceral transplantation was recognized, as it has a protective role in preventing rejection of simultaneously transplanted solid organs such as kidney and heart. The liver has a unique architecture and is home to many cells involved in immunity and inflammation. After transplantation, these cells migrate from the liver into the recipient. Early studies identified chimerism as an important mechanism by which the liver modulates the human immune system. Recent studies on human T-cell subtypes, cytokine expression, and gene expression in the allograft have expanded our knowledge on the potential mechanisms underlying immunomodulation. In this article, we discuss the privileged state of liver transplantation compared to other solid organ transplantation, the liver allograft's role in multivisceral transplantation, various cells in the liver involved in immune responses, and the potential mechanisms underlying immunomodulation of host alloresponses.
KW - Alloimmunity
KW - Liver transplantation
KW - Liver-kidney transplant
KW - Rejection
KW - Tolerance
UR - http://www.scopus.com/inward/record.url?scp=85068873061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068873061&partnerID=8YFLogxK
U2 - 10.3748/wjg.v25.i25.3123
DO - 10.3748/wjg.v25.i25.3123
M3 - Review article
C2 - 31333306
AN - SCOPUS:85068873061
VL - 25
SP - 3123
EP - 3135
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 25
ER -