Revised criterion for diagnosis of ineffective esophageal motility is associated with more frequent dysphagia and greater bolus transit abnormalities

Wojciech Blonski, Marcelo Vela, Akber Safder, Amine Hila, Donald O. Castell

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

BACKGROUND: Ineffective esophageal motility (IEM) has been defined by the presence of ≥30% liquid swallows with contraction amplitude <30 mmHg (ineffective swallows) in the distal esophagus ("old" IEM). A recent study with combined multichannel intraluminal impedance and manometry (MII-EM) raised the question whether the manometric diagnosis of IEM should be based on a new definition: ≥50% ineffective liquid swallows ("new" IEM). The aim of this study was to evaluate the association between the number of ineffective liquid swallows and symptoms and bolus transit in patients with "new" or "old" IEM who underwent MII-EM studies using 10 liquid and 10 viscous swallows. MATERIALS AND METHODS: There were 150 patients with "old" IEM included in the study. The patients diagnosed with "old" IEM (N = 150) (group A) were compared with those who retained a manometric diagnosis of IEM by the new definition (N = 101) (group B). The patients who did not retain their manometric diagnosis of IEM by the new definition (N = 49) (group C) were compared with group B. IEM was characterized as mild (normal bolus transit for both liquid and viscous swallows), moderate (abnormal bolus transit either for liquid or viscous swallows), or severe (abnormal bolus transit for both liquid and viscous swallows). RESULTS: There was no statistical difference in frequency of mild, moderate, or severe IEM and frequency of symptoms between group A and B. Group C had a significantly higher frequency of mild IEM and significantly lower frequency of severe IEM than group B. Heartburn (25.7% vs 10.2%, P = 0.03) and dysphagia (24.8% vs 12.3%, P = 0.08) showed a trend towards a greater frequency in group B than in group C. CONCLUSION: Our study indicates that IEM with ≥50% ineffective liquid swallows is frequently associated with bolus transit abnormalities and esophageal symptoms. Our results underscore the rationale for using the new definition of IEM.

Original languageEnglish (US)
Pages (from-to)699-704
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume103
Issue number3
DOIs
StatePublished - Mar 2008
Externally publishedYes

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Swallows
Deglutition Disorders
Manometry
Electric Impedance
Heartburn
Esophagus

ASJC Scopus subject areas

  • Gastroenterology

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Revised criterion for diagnosis of ineffective esophageal motility is associated with more frequent dysphagia and greater bolus transit abnormalities. / Blonski, Wojciech; Vela, Marcelo; Safder, Akber; Hila, Amine; Castell, Donald O.

In: American Journal of Gastroenterology, Vol. 103, No. 3, 03.2008, p. 699-704.

Research output: Contribution to journalArticle

Blonski, Wojciech ; Vela, Marcelo ; Safder, Akber ; Hila, Amine ; Castell, Donald O. / Revised criterion for diagnosis of ineffective esophageal motility is associated with more frequent dysphagia and greater bolus transit abnormalities. In: American Journal of Gastroenterology. 2008 ; Vol. 103, No. 3. pp. 699-704.
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abstract = "BACKGROUND: Ineffective esophageal motility (IEM) has been defined by the presence of ≥30{\%} liquid swallows with contraction amplitude <30 mmHg (ineffective swallows) in the distal esophagus ({"}old{"} IEM). A recent study with combined multichannel intraluminal impedance and manometry (MII-EM) raised the question whether the manometric diagnosis of IEM should be based on a new definition: ≥50{\%} ineffective liquid swallows ({"}new{"} IEM). The aim of this study was to evaluate the association between the number of ineffective liquid swallows and symptoms and bolus transit in patients with {"}new{"} or {"}old{"} IEM who underwent MII-EM studies using 10 liquid and 10 viscous swallows. MATERIALS AND METHODS: There were 150 patients with {"}old{"} IEM included in the study. The patients diagnosed with {"}old{"} IEM (N = 150) (group A) were compared with those who retained a manometric diagnosis of IEM by the new definition (N = 101) (group B). The patients who did not retain their manometric diagnosis of IEM by the new definition (N = 49) (group C) were compared with group B. IEM was characterized as mild (normal bolus transit for both liquid and viscous swallows), moderate (abnormal bolus transit either for liquid or viscous swallows), or severe (abnormal bolus transit for both liquid and viscous swallows). RESULTS: There was no statistical difference in frequency of mild, moderate, or severe IEM and frequency of symptoms between group A and B. Group C had a significantly higher frequency of mild IEM and significantly lower frequency of severe IEM than group B. Heartburn (25.7{\%} vs 10.2{\%}, P = 0.03) and dysphagia (24.8{\%} vs 12.3{\%}, P = 0.08) showed a trend towards a greater frequency in group B than in group C. CONCLUSION: Our study indicates that IEM with ≥50{\%} ineffective liquid swallows is frequently associated with bolus transit abnormalities and esophageal symptoms. Our results underscore the rationale for using the new definition of IEM.",
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T1 - Revised criterion for diagnosis of ineffective esophageal motility is associated with more frequent dysphagia and greater bolus transit abnormalities

AU - Blonski, Wojciech

AU - Vela, Marcelo

AU - Safder, Akber

AU - Hila, Amine

AU - Castell, Donald O.

PY - 2008/3

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N2 - BACKGROUND: Ineffective esophageal motility (IEM) has been defined by the presence of ≥30% liquid swallows with contraction amplitude <30 mmHg (ineffective swallows) in the distal esophagus ("old" IEM). A recent study with combined multichannel intraluminal impedance and manometry (MII-EM) raised the question whether the manometric diagnosis of IEM should be based on a new definition: ≥50% ineffective liquid swallows ("new" IEM). The aim of this study was to evaluate the association between the number of ineffective liquid swallows and symptoms and bolus transit in patients with "new" or "old" IEM who underwent MII-EM studies using 10 liquid and 10 viscous swallows. MATERIALS AND METHODS: There were 150 patients with "old" IEM included in the study. The patients diagnosed with "old" IEM (N = 150) (group A) were compared with those who retained a manometric diagnosis of IEM by the new definition (N = 101) (group B). The patients who did not retain their manometric diagnosis of IEM by the new definition (N = 49) (group C) were compared with group B. IEM was characterized as mild (normal bolus transit for both liquid and viscous swallows), moderate (abnormal bolus transit either for liquid or viscous swallows), or severe (abnormal bolus transit for both liquid and viscous swallows). RESULTS: There was no statistical difference in frequency of mild, moderate, or severe IEM and frequency of symptoms between group A and B. Group C had a significantly higher frequency of mild IEM and significantly lower frequency of severe IEM than group B. Heartburn (25.7% vs 10.2%, P = 0.03) and dysphagia (24.8% vs 12.3%, P = 0.08) showed a trend towards a greater frequency in group B than in group C. CONCLUSION: Our study indicates that IEM with ≥50% ineffective liquid swallows is frequently associated with bolus transit abnormalities and esophageal symptoms. Our results underscore the rationale for using the new definition of IEM.

AB - BACKGROUND: Ineffective esophageal motility (IEM) has been defined by the presence of ≥30% liquid swallows with contraction amplitude <30 mmHg (ineffective swallows) in the distal esophagus ("old" IEM). A recent study with combined multichannel intraluminal impedance and manometry (MII-EM) raised the question whether the manometric diagnosis of IEM should be based on a new definition: ≥50% ineffective liquid swallows ("new" IEM). The aim of this study was to evaluate the association between the number of ineffective liquid swallows and symptoms and bolus transit in patients with "new" or "old" IEM who underwent MII-EM studies using 10 liquid and 10 viscous swallows. MATERIALS AND METHODS: There were 150 patients with "old" IEM included in the study. The patients diagnosed with "old" IEM (N = 150) (group A) were compared with those who retained a manometric diagnosis of IEM by the new definition (N = 101) (group B). The patients who did not retain their manometric diagnosis of IEM by the new definition (N = 49) (group C) were compared with group B. IEM was characterized as mild (normal bolus transit for both liquid and viscous swallows), moderate (abnormal bolus transit either for liquid or viscous swallows), or severe (abnormal bolus transit for both liquid and viscous swallows). RESULTS: There was no statistical difference in frequency of mild, moderate, or severe IEM and frequency of symptoms between group A and B. Group C had a significantly higher frequency of mild IEM and significantly lower frequency of severe IEM than group B. Heartburn (25.7% vs 10.2%, P = 0.03) and dysphagia (24.8% vs 12.3%, P = 0.08) showed a trend towards a greater frequency in group B than in group C. CONCLUSION: Our study indicates that IEM with ≥50% ineffective liquid swallows is frequently associated with bolus transit abnormalities and esophageal symptoms. Our results underscore the rationale for using the new definition of IEM.

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