Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages

Jean François Emile, Oussama Abla, Sylvie Fraitag, Annacarin Horne, Julien Haroche, Jean Donadieu, Luis Requena-Caballero, Michael B. Jordan, Omar Abdel-Wahab, Carl E. Allen, Frédéric Charlotte, Eli L. Diamond, R. Maarten Egeler, Alain Fischer, Juana Gil Herrera, Jan Inge Henter, Filip Janku, Miriam Merad, Jennifer Picarsic, Carlos Rodriguez-GalindoBarret J. Rollins, Abdellatif Tazi, Robert Vassallo, Lawrence M. Weiss, Society Histiocyte Society

Research output: Contribution to journalReview article

277 Citations (Scopus)

Abstract

The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.

Original languageEnglish (US)
Pages (from-to)2672-2681
Number of pages10
JournalBlood
Volume127
Issue number22
DOIs
StatePublished - Jun 2 2016

Fingerprint

Histiocytosis
Macrophages
Cell Lineage
Dendritic Cells
Histology
Macrophage Activation Syndrome
Sinus Histiocytosis
Histiocytic Sarcoma
Hemophagocytic Lymphohistiocytosis
Neoplasms
Molecular Pathology
Pathology
Monocytes
Chemical activation
Guidelines
Tissue
Phenotype
Imaging techniques
Skin

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Emile, J. F., Abla, O., Fraitag, S., Horne, A., Haroche, J., Donadieu, J., ... Histiocyte Society, S. (2016). Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood, 127(22), 2672-2681. https://doi.org/10.1182/blood-2016-01-690636

Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. / Emile, Jean François; Abla, Oussama; Fraitag, Sylvie; Horne, Annacarin; Haroche, Julien; Donadieu, Jean; Requena-Caballero, Luis; Jordan, Michael B.; Abdel-Wahab, Omar; Allen, Carl E.; Charlotte, Frédéric; Diamond, Eli L.; Egeler, R. Maarten; Fischer, Alain; Herrera, Juana Gil; Henter, Jan Inge; Janku, Filip; Merad, Miriam; Picarsic, Jennifer; Rodriguez-Galindo, Carlos; Rollins, Barret J.; Tazi, Abdellatif; Vassallo, Robert; Weiss, Lawrence M.; Histiocyte Society, Society.

In: Blood, Vol. 127, No. 22, 02.06.2016, p. 2672-2681.

Research output: Contribution to journalReview article

Emile, JF, Abla, O, Fraitag, S, Horne, A, Haroche, J, Donadieu, J, Requena-Caballero, L, Jordan, MB, Abdel-Wahab, O, Allen, CE, Charlotte, F, Diamond, EL, Egeler, RM, Fischer, A, Herrera, JG, Henter, JI, Janku, F, Merad, M, Picarsic, J, Rodriguez-Galindo, C, Rollins, BJ, Tazi, A, Vassallo, R, Weiss, LM & Histiocyte Society, S 2016, 'Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages', Blood, vol. 127, no. 22, pp. 2672-2681. https://doi.org/10.1182/blood-2016-01-690636
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood. 2016 Jun 2;127(22):2672-2681. https://doi.org/10.1182/blood-2016-01-690636
Emile, Jean François ; Abla, Oussama ; Fraitag, Sylvie ; Horne, Annacarin ; Haroche, Julien ; Donadieu, Jean ; Requena-Caballero, Luis ; Jordan, Michael B. ; Abdel-Wahab, Omar ; Allen, Carl E. ; Charlotte, Frédéric ; Diamond, Eli L. ; Egeler, R. Maarten ; Fischer, Alain ; Herrera, Juana Gil ; Henter, Jan Inge ; Janku, Filip ; Merad, Miriam ; Picarsic, Jennifer ; Rodriguez-Galindo, Carlos ; Rollins, Barret J. ; Tazi, Abdellatif ; Vassallo, Robert ; Weiss, Lawrence M. ; Histiocyte Society, Society. / Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. In: Blood. 2016 ; Vol. 127, No. 22. pp. 2672-2681.
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