Review article: The diagnosis of coeliac disease

A. S. Abdulkarim, J. A. Murray

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

Coeliac disease is a chronic inflammatory condition associated with small intestinal injury that results in the malabsorption of different nutrients. The damaging factor is gluten present in wheat, barley and rye. The diagnosis relies on the clinical picture of the patient. serological markers for coeliac disease, characteristic findings of small intestinal biopsy and, eventually, clinical improvement on a gluten-free diet. Our strategies for the diagnosis of coeliac disease have changed dramatically within the last 10 years. The advent of serological markers with high sensitivity and specificity is changing our understanding of the disease and its prevalence. Treatment includes a life-long gluten-free diet to prevent the recurrence of symptoms and other potential consequences. Most coeliac disease remains under-diagnosed; the utilization of more accurate serological tests and a greater awareness of its many presentations will aid its identification.

Original languageEnglish (US)
Pages (from-to)987-995
Number of pages9
JournalAlimentary Pharmacology and Therapeutics
Volume17
Issue number8
DOIs
StatePublished - Apr 15 2003

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ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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