We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.
|Original language||English (US)|
|Number of pages||2|
|Journal||American journal of hematology|
|State||Published - Feb 1994|
- dimethylsulfoxide toxiclty
- perpheral blood stem cell transplant
ASJC Scopus subject areas