Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion

Madhav Dhodapkar; Stuart L. Goldberg; Ayalew Tefferi; Morse A. Gertz

doi:10.1002/ajh.2830450218

Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion

Madhav Dhodapkar, Stuart L. Goldberg, Ayalew Tefferi, Morse A. Gertz

Hematology

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.

Original language	English (US)
Pages (from-to)	187-188
Number of pages	2
Journal	American journal of hematology
Volume	45
Issue number	2
DOIs	https://doi.org/10.1002/ajh.2830450218
State	Published - Feb 1994

Keywords

dimethylsulfoxide toxiclty
encephalopathy
perpheral blood stem cell transplant

ASJC Scopus subject areas

Hematology

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10.1002/ajh.2830450218

Cite this

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title = "Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion",

abstract = "We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. {\textcopyright} 1994 Wiley‐Liss, Inc.",

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author = "Madhav Dhodapkar and Goldberg, {Stuart L.} and Ayalew Tefferi and Gertz, {Morse A.}",

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AB - We report two patients who experienced severe reversible encephalopathy following infusion of peripheral blood stem cells cryopreserved in 10% dimethylsulfoxide (DMSO). In one patient, reduction of DMSO level with plasmapheresis resulted in marked improvement in encephalopathy. Infusion of large volumes of cryopreserved stem cells may result in a signiflcant toxlc reaction. Plasmapheresis may be a treatment option for patients with significant toxicity related to DMSO. © 1994 Wiley‐Liss, Inc.

KW - dimethylsulfoxide toxiclty

KW - encephalopathy

KW - perpheral blood stem cell transplant

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Reversible encephalopathy after cryopreserved peripheral blood stem cell infusion

Abstract

Keywords

ASJC Scopus subject areas

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