Reversible cerebral vasoconstriction syndrome

Holly Yancy; Joyce Kerri Lee Iannotti; Todd J. Schwedt; David W. Dodick

doi:10.1111/head.12040

Reversible cerebral vasoconstriction syndrome

Holly Yancy, Joyce Kerri Lee Iannotti, Todd J. Schwedt, David W. Dodick

Neurology

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular disorder with a clinical picture that continues to be refined. It has presented to multiple subspecialties over the past several decades, bringing with it many questions regarding risk factors, diagnosis, and management. Answers have been forthcoming but many questions remain. RCVS presents with recurrent, secondary thunderclap headaches and predominantly affects young women. The mechanism of vasoconstriction is unclear, but there has been speculation regarding a hyperadrenergic state. Diagnosis requires physician awareness, vascular imaging, and knowledge of the differential. The hallmark of its diagnosis is reversibility. Management is empiric, usually with calcium-channel blockers, as there are no controlled treatment trials for RCVS. Randomized controlled trials are needed.

Original language	English (US)
Pages (from-to)	570-576
Number of pages	7
Journal	Headache
Volume	53
Issue number	3
DOIs	https://doi.org/10.1111/head.12040
State	Published - Mar 1 2013

Keywords

Call-Fleming syndrome
benign angiopathy of the central nervous system
reversible cerebral vasoconstriction syndrome

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1111/head.12040

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title = "Reversible cerebral vasoconstriction syndrome",

abstract = "Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular disorder with a clinical picture that continues to be refined. It has presented to multiple subspecialties over the past several decades, bringing with it many questions regarding risk factors, diagnosis, and management. Answers have been forthcoming but many questions remain. RCVS presents with recurrent, secondary thunderclap headaches and predominantly affects young women. The mechanism of vasoconstriction is unclear, but there has been speculation regarding a hyperadrenergic state. Diagnosis requires physician awareness, vascular imaging, and knowledge of the differential. The hallmark of its diagnosis is reversibility. Management is empiric, usually with calcium-channel blockers, as there are no controlled treatment trials for RCVS. Randomized controlled trials are needed.",

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