Purpose: To document reversible corneal edema caused by amantadine in a pediatric patient. Methods: A 14-year-old boy with a neurologic tremor was referred for bilateral visual loss. Our examination disclosed bilateral corneal edema without ocular inflammation. Pachymetry confirmed significantly increased corneal thickness above 900 μm. Results: Review of the patient's medical information revealed recent institution of amantadine as a means to control the patient's tremor. On cessation of this agent, rapid resolution of corneal edema and recovery of visual acuity occurred. Repeat pachymetry measurement revealed normal corneal thickness. Conclusion: In cases of corneal edema and in the absence of any identifiable ocular causes, a review of toxic effects of systemic medication should be undertaken. Amantadine can cause corneal decompensation and needs to be considered as part of the differential diagnosis of corneal edema.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Nov 1 2004|
- Corneal edema
- Drug-induced ocular toxicity
ASJC Scopus subject areas