Abstract
The present study examines how FUra substitution alters the ability of an RNA molecule to serve as a template for reverse transcription. We observe that reverse transcription of FUra-substituted RNAs is severely impaired at pH 8.8, but not at pH 7.8, while unsubstituted RNAs serve as efficient templates under both conditions.
Original language | English (US) |
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Pages (from-to) | 1423-1432 |
Number of pages | 10 |
Journal | Nucleosides and Nucleotides |
Volume | 15 |
Issue number | 7-8 |
DOIs | |
State | Published - Jan 1 1996 |
ASJC Scopus subject areas
- Biochemistry
- Genetics