Abstract
The present study examines how FUra substitution alters the ability of an RNA molecule to serve as a template for reverse transcription. We observe that reverse transcription of FUra-substituted RNAs is severely impaired at pH 8.8, but not at pH 7.8, while unsubstituted RNAs serve as efficient templates under both conditions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1423-1432 |
| Number of pages | 10 |
| Journal | Nucleosides and Nucleotides |
| Volume | 15 |
| Issue number | 7-8 |
| DOIs | |
| State | Published - Jan 1 1996 |
ASJC Scopus subject areas
- Biochemistry
- Genetics
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Cite this
Fisher, T., & Maher, L. J. (1996). Reverse transcription of 5-fluorouracil-substituted RNA. Nucleosides and Nucleotides, 15(7-8), 1423-1432. https://doi.org/10.1080/07328319608002441