Reverse transcription of 5-fluorouracil-substituted RNA

Tim Fisher, L. James Maher

Research output: Contribution to journalArticle

1 Scopus citations


The present study examines how FUra substitution alters the ability of an RNA molecule to serve as a template for reverse transcription. We observe that reverse transcription of FUra-substituted RNAs is severely impaired at pH 8.8, but not at pH 7.8, while unsubstituted RNAs serve as efficient templates under both conditions.

Original languageEnglish (US)
Pages (from-to)1423-1432
Number of pages10
JournalNucleosides and Nucleotides
Issue number7-8
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

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