TY - JOUR
T1 - Return of motor function after repair of a 3-cm gap in a rabbit peroneal nerve
T2 - A comparison of autograft, collagen conduit, and conduit filled with collagen-GAG matrix
AU - Sahakyants, Tatevik
AU - Lee, Joo Yup
AU - Friedrich, Patricia F.
AU - Bishop, Allen T.
AU - Shin, Alexander Y.
N1 - Funding Information:
The study was supported by a grant from Integra LifeSciences.
PY - 2013/11/6
Y1 - 2013/11/6
N2 - Background: The purpose of this study was to evaluate the motor nerve recovery in a rabbit model after repair of a 3-cm gap in the peroneal nerve with a conduit filled with a collagen-GAG (glycosaminoglycan) matrix and compare the results with those after reconstruction with an autograft or an empty collagen conduit. Methods: Forty-twomale New Zealand rabbits were divided into three experimental groups. In each group, a unilateral 3-cm peroneal nerve defect was repaired with a nerve autograft, an empty collagen conduit, or a conduit filled with a collagen-GAG matrix. At six months, nerve regeneration was evaluated on the basis of the compound muscle action potentials, maximum isometric tetanic force, and wet muscle weight of the tibialis anterior muscle as well as nerve histomorphometry. Results: The autograft group had significantly better motor recovery than the conduit groups. The empty collagen conduits and conduits filled with the collagen-GAG matrix led to results that were similar to each other. Conclusions: On the basis of this rabbit model, autologous nerve grafting remains the gold standard in the reconstruction of 3-cm segmental motor nerve defects. Clinical Relevance: Segmental motor nerve defects should be reconstructed with autograft nerves. The use of a collagen conduit filled with a collagen-GAG matrix for motor nerve reconstruction should be limited until additional animal studies are performed.
AB - Background: The purpose of this study was to evaluate the motor nerve recovery in a rabbit model after repair of a 3-cm gap in the peroneal nerve with a conduit filled with a collagen-GAG (glycosaminoglycan) matrix and compare the results with those after reconstruction with an autograft or an empty collagen conduit. Methods: Forty-twomale New Zealand rabbits were divided into three experimental groups. In each group, a unilateral 3-cm peroneal nerve defect was repaired with a nerve autograft, an empty collagen conduit, or a conduit filled with a collagen-GAG matrix. At six months, nerve regeneration was evaluated on the basis of the compound muscle action potentials, maximum isometric tetanic force, and wet muscle weight of the tibialis anterior muscle as well as nerve histomorphometry. Results: The autograft group had significantly better motor recovery than the conduit groups. The empty collagen conduits and conduits filled with the collagen-GAG matrix led to results that were similar to each other. Conclusions: On the basis of this rabbit model, autologous nerve grafting remains the gold standard in the reconstruction of 3-cm segmental motor nerve defects. Clinical Relevance: Segmental motor nerve defects should be reconstructed with autograft nerves. The use of a collagen conduit filled with a collagen-GAG matrix for motor nerve reconstruction should be limited until additional animal studies are performed.
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U2 - 10.2106/JBJS.M.00215
DO - 10.2106/JBJS.M.00215
M3 - Article
C2 - 24196465
AN - SCOPUS:84891609591
SN - 0021-9355
VL - 95
SP - 1952
EP - 1958
JO - Journal of Bone and Joint Surgery
JF - Journal of Bone and Joint Surgery
IS - 21
ER -