Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay

Brian G Weinshenker, G. Dekaban, G. P A Rice

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

Original languageEnglish (US)
Pages (from-to)1251-1253
Number of pages3
JournalNeurology
Volume40
Issue number8
StatePublished - Aug 1990
Externally publishedYes

Fingerprint

Caprine Arthritis-Encephalitis Viruses
Retroviridae
Multiple Sclerosis
HIV-1
Human T-lymphotropic virus 1
Western Blotting
HTLV-I Antibodies
Retroviridae Infections
Nervous System Diseases
Enzyme-Linked Immunosorbent Assay
Antibodies

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay. / Weinshenker, Brian G; Dekaban, G.; Rice, G. P A.

In: Neurology, Vol. 40, No. 8, 08.1990, p. 1251-1253.

Research output: Contribution to journalArticle

@article{42a66c2d4a6b42319bf711f6aaaf237f,
title = "Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay",
abstract = "We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.",
author = "Weinshenker, {Brian G} and G. Dekaban and Rice, {G. P A}",
year = "1990",
month = "8",
language = "English (US)",
volume = "40",
pages = "1251--1253",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay

AU - Weinshenker, Brian G

AU - Dekaban, G.

AU - Rice, G. P A

PY - 1990/8

Y1 - 1990/8

N2 - We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

AB - We were unable to identify an antibody to either HTLV-I or HIV-1 in patients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

UR - http://www.scopus.com/inward/record.url?scp=0024986419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024986419&partnerID=8YFLogxK

M3 - Article

C2 - 2381534

AN - SCOPUS:0024986419

VL - 40

SP - 1251

EP - 1253

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 8

ER -