Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay

B. G. Weinshenker, G. Dekaban, G. P.A. Rice

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We were unable to identify an antibody to either HTLV-I or HIV-1 inpatients with multiple sclerosis (MS) by ELISA, by radioimmune assay, or by radioimmune precipitation techniques. Immunoblot studies for HTLV-I-specific antibodies revealed faintly reactive bands in 2 of 44 MS patients but not in patients with other neurologic diseases. We did not find seroreactivity to HIV-1 or to the distantly related retrovirus, caprine arthritis encephalitis virus (CAEV). These findings suggest that MS is not related to infection by human retroviruses with antigenic similarity to HTLV-I, HIV-1, or CAEV.

Original languageEnglish (US)
Pages (from-to)1251-1253
Number of pages3
JournalNeurology
Volume40
Issue number8
DOIs
StatePublished - Aug 1990

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Retroviruses and multiple sclerosis. I. Analysis of seroreactivity by Western blot and radioimmune assay'. Together they form a unique fingerprint.

  • Cite this