Retroviral pseudotypes produced by rescue of a moloney murine leukemia virus vector by C-type, but not D-type, retroviruses

Yasuhiro Takeuchi, Guy Simpson, Richard G. Vile, Robin A. Weiss, Mary K.L. Collins

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Human HOS cells containing a Moloney murine leukemia virus (Mo-MLV) recombinant genome were infected by a panel of retroviruses. The C-type viruses simian sarcoma associated virus, feline leukemia virus subgroup B, and the feline endogenous virus RD114 were able to form pseudotypes with the Mo-MLV genome, which transferred a selectable marker gene to target cells; however, Human T cell leukemia virus-1 and the D-type viruses Mason-Pfizer monkey virus and simian retrovirus-1 failed to rescue the Mo-MLV vector. Further characterization of the RD114 pseudotype demonstrated that it retained the receptor specificity of RD114 and will therefore prove useful in receptor characterization.

Original languageEnglish (US)
Pages (from-to)792-794
Number of pages3
JournalVirology
Volume186
Issue number2
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Virology

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