Retroviral pseudotypes produced by rescue of a moloney murine leukemia virus vector by C-type, but not D-type, retroviruses

Yasuhiro Takeuchi; Guy Simpson; Richard G. Vile; Robin A. Weiss; Mary K.L. Collins

doi:10.1016/0042-6822(92)90049-U

Retroviral pseudotypes produced by rescue of a moloney murine leukemia virus vector by C-type, but not D-type, retroviruses

Yasuhiro Takeuchi, Guy Simpson, Richard G. Vile, Robin A. Weiss, Mary K.L. Collins

Molecular Medicine

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39 Scopus citations

Abstract

Human HOS cells containing a Moloney murine leukemia virus (Mo-MLV) recombinant genome were infected by a panel of retroviruses. The C-type viruses simian sarcoma associated virus, feline leukemia virus subgroup B, and the feline endogenous virus RD114 were able to form pseudotypes with the Mo-MLV genome, which transferred a selectable marker gene to target cells; however, Human T cell leukemia virus-1 and the D-type viruses Mason-Pfizer monkey virus and simian retrovirus-1 failed to rescue the Mo-MLV vector. Further characterization of the RD114 pseudotype demonstrated that it retained the receptor specificity of RD114 and will therefore prove useful in receptor characterization.

Original language	English (US)
Pages (from-to)	792-794
Number of pages	3
Journal	Virology
Volume	186
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(92)90049-U
State	Published - Feb 1992

ASJC Scopus subject areas

Virology

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10.1016/0042-6822(92)90049-U

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title = "Retroviral pseudotypes produced by rescue of a moloney murine leukemia virus vector by C-type, but not D-type, retroviruses",

abstract = "Human HOS cells containing a Moloney murine leukemia virus (Mo-MLV) recombinant genome were infected by a panel of retroviruses. The C-type viruses simian sarcoma associated virus, feline leukemia virus subgroup B, and the feline endogenous virus RD114 were able to form pseudotypes with the Mo-MLV genome, which transferred a selectable marker gene to target cells; however, Human T cell leukemia virus-1 and the D-type viruses Mason-Pfizer monkey virus and simian retrovirus-1 failed to rescue the Mo-MLV vector. Further characterization of the RD114 pseudotype demonstrated that it retained the receptor specificity of RD114 and will therefore prove useful in receptor characterization.",

author = "Yasuhiro Takeuchi and Guy Simpson and Vile, {Richard G.} and Weiss, {Robin A.} and Collins, {Mary K.L.}",

note = "Funding Information: This work was supported by the Cancer Research Campaign, the Leukemia Research Fund, the Wellcome Trust, and the Japan Health Sciences Foundation.",

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AU - Takeuchi, Yasuhiro

AU - Simpson, Guy

AU - Vile, Richard G.

AU - Weiss, Robin A.

AU - Collins, Mary K.L.

N1 - Funding Information: This work was supported by the Cancer Research Campaign, the Leukemia Research Fund, the Wellcome Trust, and the Japan Health Sciences Foundation.

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N2 - Human HOS cells containing a Moloney murine leukemia virus (Mo-MLV) recombinant genome were infected by a panel of retroviruses. The C-type viruses simian sarcoma associated virus, feline leukemia virus subgroup B, and the feline endogenous virus RD114 were able to form pseudotypes with the Mo-MLV genome, which transferred a selectable marker gene to target cells; however, Human T cell leukemia virus-1 and the D-type viruses Mason-Pfizer monkey virus and simian retrovirus-1 failed to rescue the Mo-MLV vector. Further characterization of the RD114 pseudotype demonstrated that it retained the receptor specificity of RD114 and will therefore prove useful in receptor characterization.

AB - Human HOS cells containing a Moloney murine leukemia virus (Mo-MLV) recombinant genome were infected by a panel of retroviruses. The C-type viruses simian sarcoma associated virus, feline leukemia virus subgroup B, and the feline endogenous virus RD114 were able to form pseudotypes with the Mo-MLV genome, which transferred a selectable marker gene to target cells; however, Human T cell leukemia virus-1 and the D-type viruses Mason-Pfizer monkey virus and simian retrovirus-1 failed to rescue the Mo-MLV vector. Further characterization of the RD114 pseudotype demonstrated that it retained the receptor specificity of RD114 and will therefore prove useful in receptor characterization.

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Retroviral pseudotypes produced by rescue of a moloney murine leukemia virus vector by C-type, but not D-type, retroviruses

Abstract

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