Retrograde transport in corticospinal neurons after spinal cord transection

Earl R. Feringa, H. Lee Vahlsing, Benn E. Smith

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.

Original languageEnglish (US)
Pages (from-to)478-482
Number of pages5
JournalNeurology
Volume33
Issue number4
DOIs
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Clinical Neurology

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