Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study

Jennifer A. Deal, A. Richey Sharrett, Marilyn Albert, Karen Bandeen-Roche, Sheila Burgard, Sonia Davis Thomas, Rebecca F. Gottesman, David S Knopman, Thomas Mosley, Barbara Klein, Ronald Klein

Research output: Contribution to journalArticle

Abstract

Introduction: The easily-imaged retinal microvasculature may reflect the brain microvasculature and therefore be related to dementia. Methods: In a population-based study of 12,482 adults aged 50-73 years (22% African American), we estimated the relationship of retinal characteristics from fundus photography (1993-1995) with incident all-cause dementia (1993-1995 to 2011-2013) and with etiologic subtype of dementia/mild cognitive impairment (2011-13). Results: A total of 1259 (10%) participants developed dementia over a mean 15.6 years. Moderate/severe (vs. no) retinopathy (hazard ratio [HR], 1.86; 95% confidence interval [CI]: 1.36–2.55) and central retinal arteriolar equivalent (narrowest quartile vs. widest three quartiles; HR, 1.26; 95% CI: 1.09–1.45) were associated with all-cause dementia. Results were qualitatively stronger (but not statistically significantly different) in participants with diabetes. Retinopathy was associated with a joint outcome of cerebrovascular-related, but not Alzheimer's disease–related, dementia/mild cognitive impairment (HR, 2.29; 95% CI: 1.24–4.23). Discussion: Exploration of measures in the eye may provide surrogate indices of microvascular lesions relevant to dementia.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateAccepted/In press - Jan 1 2018

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Dementia
Atherosclerosis
Confidence Intervals
Microvessels
Photography
African Americans
Alzheimer Disease
Brain
Population
Cognitive Dysfunction

Keywords

  • Cohort studies
  • Dementia
  • Diabetes
  • Microvasculature
  • Retinal
  • Risk factors in epidemiology

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health

Cite this

Deal, J. A., Sharrett, A. R., Albert, M., Bandeen-Roche, K., Burgard, S., Thomas, S. D., ... Klein, R. (Accepted/In press). Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2018.10.002

Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study. / Deal, Jennifer A.; Sharrett, A. Richey; Albert, Marilyn; Bandeen-Roche, Karen; Burgard, Sheila; Thomas, Sonia Davis; Gottesman, Rebecca F.; Knopman, David S; Mosley, Thomas; Klein, Barbara; Klein, Ronald.

In: Alzheimer's and Dementia, 01.01.2018.

Research output: Contribution to journalArticle

Deal, JA, Sharrett, AR, Albert, M, Bandeen-Roche, K, Burgard, S, Thomas, SD, Gottesman, RF, Knopman, DS, Mosley, T, Klein, B & Klein, R 2018, 'Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study', Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2018.10.002
Deal, Jennifer A. ; Sharrett, A. Richey ; Albert, Marilyn ; Bandeen-Roche, Karen ; Burgard, Sheila ; Thomas, Sonia Davis ; Gottesman, Rebecca F. ; Knopman, David S ; Mosley, Thomas ; Klein, Barbara ; Klein, Ronald. / Retinal signs and risk of incident dementia in the Atherosclerosis Risk in Communities study. In: Alzheimer's and Dementia. 2018.
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