Retinal microvascular signs and 10-year risk of cerebral atrophy: The atherosclerosis risk in communities (ARIC) study

Ryo Kawasaki, Ning Cheung, Thomas Mosley, Amirul F M Islam, A. Richey Sharrett, Ronald Klein, Laura H. Coker, David S Knopman, Dean K. Shibata, Diane Catellier, Tien Y. Wong

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background and Purpose-: Cerebral atrophy, detected as ventricular enlargement or sulcal widening on MRI, is recognized as a risk factor for vascular dementia or Alzheimer disease. However, its underlying pathophysiology is not known. We examined whether retinal microvascular assessment could provide predictive information on the risk of ventricular enlargement and sulcal widening on MRI. Methods-: A prospective, population-based study was conducted of 810 middle-aged persons without clinical stroke or MRI infarcts. All participants had a first cranial MRI and retinal photography in 1993 to 1995 and returned for a repeated MRI in 2004 to 2006 (median follow-up of 10.5 years). Retinal photographs were graded for presence of retinopathy and retinal microvascular abnormalities, and MRI images were graded for ventricular size and sulcal size according to standardized protocols. Ventricular enlargement and sulcal widening were defined as an increase in ventricular size or sulcal size of ≥3 of 10 grades between baseline and follow-up. Results-: After adjusting for age, gender, and cardiovascular risk factors, retinopathy and arteriovenous nicking at baseline were associated with 10-year ventricular enlargement (OR and 95% CI: 2.03, 1.20 to 4.42 for retinopathy and 2.19, 1.23 to 3.90 for arteriovenous nicking). Retinal signs were not associated with 10-year sulcal widening. Conclusions-: Retinopathy and arteriovenous nicking are predictive of long-term risk of ventricular enlargement, but not of sulcal widening, independent of cardiovascular risk factors. These data support a microvascular etiology for subcortical but not cortical cerebral atrophy.

Original languageEnglish (US)
Pages (from-to)1826-1828
Number of pages3
JournalStroke
Volume41
Issue number8
DOIs
StatePublished - Aug 2010

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Atrophy
Atherosclerosis
Vascular Dementia
Photography
Vascular Diseases
Alzheimer Disease
Stroke
Population

Keywords

  • cerebral atrophy
  • retinal microvascular signs
  • sulcal widening
  • ventricular enlargement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Kawasaki, R., Cheung, N., Mosley, T., Islam, A. F. M., Sharrett, A. R., Klein, R., ... Wong, T. Y. (2010). Retinal microvascular signs and 10-year risk of cerebral atrophy: The atherosclerosis risk in communities (ARIC) study. Stroke, 41(8), 1826-1828. https://doi.org/10.1161/STROKEAHA.110.585042

Retinal microvascular signs and 10-year risk of cerebral atrophy : The atherosclerosis risk in communities (ARIC) study. / Kawasaki, Ryo; Cheung, Ning; Mosley, Thomas; Islam, Amirul F M; Sharrett, A. Richey; Klein, Ronald; Coker, Laura H.; Knopman, David S; Shibata, Dean K.; Catellier, Diane; Wong, Tien Y.

In: Stroke, Vol. 41, No. 8, 08.2010, p. 1826-1828.

Research output: Contribution to journalArticle

Kawasaki, R, Cheung, N, Mosley, T, Islam, AFM, Sharrett, AR, Klein, R, Coker, LH, Knopman, DS, Shibata, DK, Catellier, D & Wong, TY 2010, 'Retinal microvascular signs and 10-year risk of cerebral atrophy: The atherosclerosis risk in communities (ARIC) study', Stroke, vol. 41, no. 8, pp. 1826-1828. https://doi.org/10.1161/STROKEAHA.110.585042
Kawasaki, Ryo ; Cheung, Ning ; Mosley, Thomas ; Islam, Amirul F M ; Sharrett, A. Richey ; Klein, Ronald ; Coker, Laura H. ; Knopman, David S ; Shibata, Dean K. ; Catellier, Diane ; Wong, Tien Y. / Retinal microvascular signs and 10-year risk of cerebral atrophy : The atherosclerosis risk in communities (ARIC) study. In: Stroke. 2010 ; Vol. 41, No. 8. pp. 1826-1828.
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AU - Kawasaki, Ryo

AU - Cheung, Ning

AU - Mosley, Thomas

AU - Islam, Amirul F M

AU - Sharrett, A. Richey

AU - Klein, Ronald

AU - Coker, Laura H.

AU - Knopman, David S

AU - Shibata, Dean K.

AU - Catellier, Diane

AU - Wong, Tien Y.

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N2 - Background and Purpose-: Cerebral atrophy, detected as ventricular enlargement or sulcal widening on MRI, is recognized as a risk factor for vascular dementia or Alzheimer disease. However, its underlying pathophysiology is not known. We examined whether retinal microvascular assessment could provide predictive information on the risk of ventricular enlargement and sulcal widening on MRI. Methods-: A prospective, population-based study was conducted of 810 middle-aged persons without clinical stroke or MRI infarcts. All participants had a first cranial MRI and retinal photography in 1993 to 1995 and returned for a repeated MRI in 2004 to 2006 (median follow-up of 10.5 years). Retinal photographs were graded for presence of retinopathy and retinal microvascular abnormalities, and MRI images were graded for ventricular size and sulcal size according to standardized protocols. Ventricular enlargement and sulcal widening were defined as an increase in ventricular size or sulcal size of ≥3 of 10 grades between baseline and follow-up. Results-: After adjusting for age, gender, and cardiovascular risk factors, retinopathy and arteriovenous nicking at baseline were associated with 10-year ventricular enlargement (OR and 95% CI: 2.03, 1.20 to 4.42 for retinopathy and 2.19, 1.23 to 3.90 for arteriovenous nicking). Retinal signs were not associated with 10-year sulcal widening. Conclusions-: Retinopathy and arteriovenous nicking are predictive of long-term risk of ventricular enlargement, but not of sulcal widening, independent of cardiovascular risk factors. These data support a microvascular etiology for subcortical but not cortical cerebral atrophy.

AB - Background and Purpose-: Cerebral atrophy, detected as ventricular enlargement or sulcal widening on MRI, is recognized as a risk factor for vascular dementia or Alzheimer disease. However, its underlying pathophysiology is not known. We examined whether retinal microvascular assessment could provide predictive information on the risk of ventricular enlargement and sulcal widening on MRI. Methods-: A prospective, population-based study was conducted of 810 middle-aged persons without clinical stroke or MRI infarcts. All participants had a first cranial MRI and retinal photography in 1993 to 1995 and returned for a repeated MRI in 2004 to 2006 (median follow-up of 10.5 years). Retinal photographs were graded for presence of retinopathy and retinal microvascular abnormalities, and MRI images were graded for ventricular size and sulcal size according to standardized protocols. Ventricular enlargement and sulcal widening were defined as an increase in ventricular size or sulcal size of ≥3 of 10 grades between baseline and follow-up. Results-: After adjusting for age, gender, and cardiovascular risk factors, retinopathy and arteriovenous nicking at baseline were associated with 10-year ventricular enlargement (OR and 95% CI: 2.03, 1.20 to 4.42 for retinopathy and 2.19, 1.23 to 3.90 for arteriovenous nicking). Retinal signs were not associated with 10-year sulcal widening. Conclusions-: Retinopathy and arteriovenous nicking are predictive of long-term risk of ventricular enlargement, but not of sulcal widening, independent of cardiovascular risk factors. These data support a microvascular etiology for subcortical but not cortical cerebral atrophy.

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KW - retinal microvascular signs

KW - sulcal widening

KW - ventricular enlargement

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