Retarded growth of murine tumors in vivo by insulin- and glucagon-stimulated immunity and phagocytosis

K. Pavelic, S. Vuk-Pavlovic

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Insulin and glucagon injected separately or simultaneously into CBA, C57BL, A, or C3Hf/Bu mice with aplastic carcinoma, fibrosarcoma, melanoma B16, Ehrlich tumor, lymphatic leukemia, or thymoma suppressed tumor growth and prolonged the mouse's mean survival time. Basic mechanistic features of growth retardation by insulin and glucagon were delineated for aplastic carcinoma and fibrosarcoma. In mice bearing these 2 tumors, stimulated plaque-forming capacity and phagocytosis were shown for these hormones. Cyclophosphamide abolished the growth retardation. Insulin- and glucagon-induced tumor suppression appeared mainly mediated by maintenance of high immune reactivity and phagocytosis.

Original languageEnglish (US)
Pages (from-to)889-892
Number of pages4
JournalJournal of the National Cancer Institute
Volume66
Issue number5
StatePublished - 1981
Externally publishedYes

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Glucagon
Phagocytosis
Immunity
Insulin
Fibrosarcoma
Growth
Neoplasms
Carcinoma
Experimental Melanomas
Thymoma
Cyclophosphamide
Leukemia
Hormones

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Retarded growth of murine tumors in vivo by insulin- and glucagon-stimulated immunity and phagocytosis. / Pavelic, K.; Vuk-Pavlovic, S.

In: Journal of the National Cancer Institute, Vol. 66, No. 5, 1981, p. 889-892.

Research output: Contribution to journalArticle

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