TY - JOUR
T1 - Retardation of schwann cell division and axonal regrowth following nerve crush in experimental lead neuropathy
AU - Ohnishi, Akio
AU - Dyck, Peter James
PY - 1981/11
Y1 - 1981/11
N2 - In experimental lead neuropathy, Schwann cells undergo segmental demyelination and possibly cell death and, concurrently, remyelination and multiplication to create new internodes of myelin and onion bulb formations. In rats fed 4% lead carbonate for three months, the ability of Schwann cells to divide (percentage showing mitotic figures, labeling index, and total number per millimeter of fascicular length of nerve) was studied serially for four weeks. Schwann cell events were also compared in sural nerve distal to crush with and without resection of an intervening length of nerve. In both cases, Schwann cell multiplication as a result of axotomy was retarded in lead‐intoxicated as compared to control animals. On the average, regrown myelinated axons four weeks after and 10 mm below the point of crush in lead‐treated animals were similar in number and smaller in caliber, but they exhibited a normal relationship of myelin thickness to axonal area compared with control animals. These studies provide evidence that Schwann cell division and axonal regrowth after crush are retarded in experimental lead neuropathy.
AB - In experimental lead neuropathy, Schwann cells undergo segmental demyelination and possibly cell death and, concurrently, remyelination and multiplication to create new internodes of myelin and onion bulb formations. In rats fed 4% lead carbonate for three months, the ability of Schwann cells to divide (percentage showing mitotic figures, labeling index, and total number per millimeter of fascicular length of nerve) was studied serially for four weeks. Schwann cell events were also compared in sural nerve distal to crush with and without resection of an intervening length of nerve. In both cases, Schwann cell multiplication as a result of axotomy was retarded in lead‐intoxicated as compared to control animals. On the average, regrown myelinated axons four weeks after and 10 mm below the point of crush in lead‐treated animals were similar in number and smaller in caliber, but they exhibited a normal relationship of myelin thickness to axonal area compared with control animals. These studies provide evidence that Schwann cell division and axonal regrowth after crush are retarded in experimental lead neuropathy.
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U2 - 10.1002/ana.410100511
DO - 10.1002/ana.410100511
M3 - Article
C2 - 7305299
AN - SCOPUS:0019481409
SN - 0364-5134
VL - 10
SP - 469
EP - 477
JO - Annals of neurology
JF - Annals of neurology
IS - 5
ER -