Retardation of schwann cell division and axonal regrowth following nerve crush in experimental lead neuropathy

Akio Ohnishi, Peter James Dyck

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

In experimental lead neuropathy, Schwann cells undergo segmental demyelination and possibly cell death and, concurrently, remyelination and multiplication to create new internodes of myelin and onion bulb formations. In rats fed 4% lead carbonate for three months, the ability of Schwann cells to divide (percentage showing mitotic figures, labeling index, and total number per millimeter of fascicular length of nerve) was studied serially for four weeks. Schwann cell events were also compared in sural nerve distal to crush with and without resection of an intervening length of nerve. In both cases, Schwann cell multiplication as a result of axotomy was retarded in lead‐intoxicated as compared to control animals. On the average, regrown myelinated axons four weeks after and 10 mm below the point of crush in lead‐treated animals were similar in number and smaller in caliber, but they exhibited a normal relationship of myelin thickness to axonal area compared with control animals. These studies provide evidence that Schwann cell division and axonal regrowth after crush are retarded in experimental lead neuropathy.

Original languageEnglish (US)
Pages (from-to)469-477
Number of pages9
JournalAnnals of neurology
Volume10
Issue number5
DOIs
StatePublished - Nov 1981

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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