Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran

J. M.S. Pascual, D. E. Runyon, James Watson, C. B. Clifford, M. A. Dubick, G. C. Kramer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A 7.5% sodium chloride/6% Dextran solution (HSD) is effective for restoration of cardiovascular function after hemorrhagic shock. In the present experiments, we tested the usefulness and side effects of a 25% NaCl/24% Dextran solution (SSD), compared to HSD and 0.9% NaCl (NS). After 1 hr of baseline observation, 21 anesthetized pigs were submitted to hemorrhagic shock, maintaining a mean arterial pressure of 45 mmHg for 60 min. Continuous intravenous infusion of one of the solutions was then initiated and the infusion rate adjusted to restore and maintain cardiac output at baseline levels for 2 hr. The NS group required 121 ± 22 ml/kg to achieve full resuscitation, while the HSD and SSD groups required 6.3 ± 1.3 and 1.7 ± 0.2 ml/kg, respectively. We conclude that SSD infusions were exceedingly effective at restoring cardiovascular function in volumes equal to only 10% of bled volume, but were associated with transient hemolysis and peripheral vein inflammation.

Original languageEnglish (US)
Pages (from-to)115-124
Number of pages10
JournalCirculatory Shock
Volume40
Issue number2
StatePublished - Jan 1 1993

Fingerprint

Silver Sulfadiazine
Hypovolemia
Dextrans
Sodium Chloride
Resuscitation
Swine
Hemorrhagic Shock
Hemolysis
Intravenous Infusions
Cardiac Output
Veins
Arterial Pressure
Observation
Inflammation

Keywords

  • acute phlebitis
  • cardiac output
  • colloidosmotic pressure
  • fluid balance
  • hemodynamics
  • hemolysis
  • hemorrhagic shock
  • hypertonic solution
  • plasma volume
  • thoracotomy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pascual, J. M. S., Runyon, D. E., Watson, J., Clifford, C. B., Dubick, M. A., & Kramer, G. C. (1993). Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran. Circulatory Shock, 40(2), 115-124.

Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran. / Pascual, J. M.S.; Runyon, D. E.; Watson, James; Clifford, C. B.; Dubick, M. A.; Kramer, G. C.

In: Circulatory Shock, Vol. 40, No. 2, 01.01.1993, p. 115-124.

Research output: Contribution to journalArticle

Pascual, JMS, Runyon, DE, Watson, J, Clifford, CB, Dubick, MA & Kramer, GC 1993, 'Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran', Circulatory Shock, vol. 40, no. 2, pp. 115-124.
Pascual JMS, Runyon DE, Watson J, Clifford CB, Dubick MA, Kramer GC. Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran. Circulatory Shock. 1993 Jan 1;40(2):115-124.
Pascual, J. M.S. ; Runyon, D. E. ; Watson, James ; Clifford, C. B. ; Dubick, M. A. ; Kramer, G. C. / Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran. In: Circulatory Shock. 1993 ; Vol. 40, No. 2. pp. 115-124.
@article{d842541cc6a440b4a643376e0191e4e1,
title = "Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran",
abstract = "A 7.5{\%} sodium chloride/6{\%} Dextran solution (HSD) is effective for restoration of cardiovascular function after hemorrhagic shock. In the present experiments, we tested the usefulness and side effects of a 25{\%} NaCl/24{\%} Dextran solution (SSD), compared to HSD and 0.9{\%} NaCl (NS). After 1 hr of baseline observation, 21 anesthetized pigs were submitted to hemorrhagic shock, maintaining a mean arterial pressure of 45 mmHg for 60 min. Continuous intravenous infusion of one of the solutions was then initiated and the infusion rate adjusted to restore and maintain cardiac output at baseline levels for 2 hr. The NS group required 121 ± 22 ml/kg to achieve full resuscitation, while the HSD and SSD groups required 6.3 ± 1.3 and 1.7 ± 0.2 ml/kg, respectively. We conclude that SSD infusions were exceedingly effective at restoring cardiovascular function in volumes equal to only 10{\%} of bled volume, but were associated with transient hemolysis and peripheral vein inflammation.",
keywords = "acute phlebitis, cardiac output, colloidosmotic pressure, fluid balance, hemodynamics, hemolysis, hemorrhagic shock, hypertonic solution, plasma volume, thoracotomy",
author = "Pascual, {J. M.S.} and Runyon, {D. E.} and James Watson and Clifford, {C. B.} and Dubick, {M. A.} and Kramer, {G. C.}",
year = "1993",
month = "1",
day = "1",
language = "English (US)",
volume = "40",
pages = "115--124",
journal = "Circulatory Shock",
issn = "0092-6213",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

TY - JOUR

T1 - Resuscitation of hypovolemia in pigs using near saturated sodium chloride solution in dextran

AU - Pascual, J. M.S.

AU - Runyon, D. E.

AU - Watson, James

AU - Clifford, C. B.

AU - Dubick, M. A.

AU - Kramer, G. C.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - A 7.5% sodium chloride/6% Dextran solution (HSD) is effective for restoration of cardiovascular function after hemorrhagic shock. In the present experiments, we tested the usefulness and side effects of a 25% NaCl/24% Dextran solution (SSD), compared to HSD and 0.9% NaCl (NS). After 1 hr of baseline observation, 21 anesthetized pigs were submitted to hemorrhagic shock, maintaining a mean arterial pressure of 45 mmHg for 60 min. Continuous intravenous infusion of one of the solutions was then initiated and the infusion rate adjusted to restore and maintain cardiac output at baseline levels for 2 hr. The NS group required 121 ± 22 ml/kg to achieve full resuscitation, while the HSD and SSD groups required 6.3 ± 1.3 and 1.7 ± 0.2 ml/kg, respectively. We conclude that SSD infusions were exceedingly effective at restoring cardiovascular function in volumes equal to only 10% of bled volume, but were associated with transient hemolysis and peripheral vein inflammation.

AB - A 7.5% sodium chloride/6% Dextran solution (HSD) is effective for restoration of cardiovascular function after hemorrhagic shock. In the present experiments, we tested the usefulness and side effects of a 25% NaCl/24% Dextran solution (SSD), compared to HSD and 0.9% NaCl (NS). After 1 hr of baseline observation, 21 anesthetized pigs were submitted to hemorrhagic shock, maintaining a mean arterial pressure of 45 mmHg for 60 min. Continuous intravenous infusion of one of the solutions was then initiated and the infusion rate adjusted to restore and maintain cardiac output at baseline levels for 2 hr. The NS group required 121 ± 22 ml/kg to achieve full resuscitation, while the HSD and SSD groups required 6.3 ± 1.3 and 1.7 ± 0.2 ml/kg, respectively. We conclude that SSD infusions were exceedingly effective at restoring cardiovascular function in volumes equal to only 10% of bled volume, but were associated with transient hemolysis and peripheral vein inflammation.

KW - acute phlebitis

KW - cardiac output

KW - colloidosmotic pressure

KW - fluid balance

KW - hemodynamics

KW - hemolysis

KW - hemorrhagic shock

KW - hypertonic solution

KW - plasma volume

KW - thoracotomy

UR - http://www.scopus.com/inward/record.url?scp=0027235673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027235673&partnerID=8YFLogxK

M3 - Article

VL - 40

SP - 115

EP - 124

JO - Circulatory Shock

JF - Circulatory Shock

SN - 0092-6213

IS - 2

ER -