Results of directional atherectomy of primary atheromatous and restenosis lesions in coronary arteries and saphenous vein grafts

Kirk N. Garratt, David Holmes, Malcolm R. Bell, Peter B. Berger, Urs P. Kaufmann, John F. Bresnahan, Ronald E. Vlietstra

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Abstract

Directional coronary atherectomy (DCA) was performed in 158 patients over a 2-year period at the Mayo Clinic. Primary atheromatous lesions were treated in 92 patients (group 1) and restenosis lesions were treated in 66 (group 2). Technical success (recovery of tissue and ≥40% luminal enlargement with a residual stenosis of <50%) was achieved in 152 lesions (92%); clinical success (technical success and no in-hospital death, Q-wave myocardial infarction or coronary bypass surgery) was achieved in 143 patients (91%). Adjunctive balloon angioplasty was used in 41 patients. DCA was successful less often in group 1 than in group 2 (86 vs 97%; p = 0.038). A major complication occurred in 7% of patients; in-hospital death, Q-wave myocardial infarction and emergency coronary bypass surgery occurred in 3, 1 and 4% of patients, respectively. Major complications were more frequent in group 1 than in group 2 (10 vs 1; p = 0.02). During a follow-up period of 14 ± 8 months, no difference between the groups was found in the incidence of late death (4%), Q-wave myocardial infarction (1%), recurrent severe angina (29%), bypass surgery (15%) or repeat interventional procedure of the same vascular segment (24%). Vein graft and restenosis lesions tended to have greater success and fewer complications. Angiographic restenosis (increase of ≥30% in stenosis severity by visual assessment) occurred in 62% of patients and 58% of lesions with successful DCA, and was similar in the 2 groups; a tendency toward higher restenosis rates was seen in patients with vein graft DCA. Late clinical events appeared to occur at rates similar to those reported for patients after balloon angioplasty. These findings support the need for a randomized, prospective trial to compare DCA with balloon angioplasty.

Original languageEnglish (US)
Pages (from-to)449-454
Number of pages6
JournalThe American journal of cardiology
Volume70
Issue number4
DOIs
StatePublished - Aug 15 1992

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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