Restriction of measles virus gene expression in measles inclusion body encephalitis

K. Baczko, U. G. Liebert, Roberto Cattaneo, M. A. Billeter, R. P. Roos, V. Ter Meulen

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Measles virus (MV) infection in brain tissue of a patient with measles inclusion body encephalitis was characterized by immunologic and biochemical techniques. Of the five major structural proteins of MV, only nucleocapsid (N) protein and phosphoprotein (P protein) were consistently detected in diseased brain areas. In contrast, hemagglutinin protein was seen only occasionally, and no membrane and fusion proteins were found in any of the sections studied. Messenger RNAs (mRNAs) specific for these five viral proteins were detected in all brain extracts examined; however, the mRNAs for the envelope proteins were clearly underrepresented in comparison with lytically infected cells. Only the mRNAs for N and P proteins appeared active in in vitro translations. These findings indicate quantitative differences in the patterns of mRNA expression in brain tissue and a restricted expression of MV envelope proteins in infected cells as observed in subacute sclerosing panencephalitis.

Original languageEnglish (US)
Pages (from-to)144-150
Number of pages7
JournalJournal of Infectious Diseases
Volume158
Issue number1
StatePublished - 1988
Externally publishedYes

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Subacute Sclerosing Panencephalitis
Measles virus
Gene Expression
Messenger RNA
Brain
Proteins
Membrane Fusion Proteins
Viral Envelope Proteins
Immunologic Techniques
Nucleocapsid Proteins
Phosphoproteins
Hemagglutinins
Brain Diseases
Viral Proteins
Virus Diseases

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Baczko, K., Liebert, U. G., Cattaneo, R., Billeter, M. A., Roos, R. P., & Ter Meulen, V. (1988). Restriction of measles virus gene expression in measles inclusion body encephalitis. Journal of Infectious Diseases, 158(1), 144-150.

Restriction of measles virus gene expression in measles inclusion body encephalitis. / Baczko, K.; Liebert, U. G.; Cattaneo, Roberto; Billeter, M. A.; Roos, R. P.; Ter Meulen, V.

In: Journal of Infectious Diseases, Vol. 158, No. 1, 1988, p. 144-150.

Research output: Contribution to journalArticle

Baczko, K, Liebert, UG, Cattaneo, R, Billeter, MA, Roos, RP & Ter Meulen, V 1988, 'Restriction of measles virus gene expression in measles inclusion body encephalitis', Journal of Infectious Diseases, vol. 158, no. 1, pp. 144-150.
Baczko, K. ; Liebert, U. G. ; Cattaneo, Roberto ; Billeter, M. A. ; Roos, R. P. ; Ter Meulen, V. / Restriction of measles virus gene expression in measles inclusion body encephalitis. In: Journal of Infectious Diseases. 1988 ; Vol. 158, No. 1. pp. 144-150.
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