Restless legs syndrome and periodic limb movements of sleep

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Patients afflicted with restless legs syndrome (RLS) experience an urge to move the limbs that most often is accompanied by unpleasant limb sensations. These symptoms are most severe at rest and improve with movement of the affected limb. In contrast to these limb movements voluntarily executed to attenuate RLS symptoms, periodic limb movements (PLM) are repetitive, highly stereotyped, involuntary movements that can occur during sleep (PLMS) or wakefulness (PLMW). Although these disorders may occur in isolation, they often are comorbid. Both RLS and PLM frequently occur in patients with Parkinson’s disease (PD), although it remains controversial whether the prevalence of these conditions is greater in PD patients than in the general population. RLS, PLM, and PD may all respond to dopaminergic medications; the degree to which the pathophysiology of these conditions overlaps is still being explored. As RLS and PLMS may be a cause of poor sleep and excessive daytime sleepiness in the PD population, effective treatment for these conditions can significantly improve the quality of life.

Original languageEnglish (US)
Title of host publicationParkinson's Disease, Second Edition
PublisherCRC Press
Pages235-248
Number of pages14
ISBN (Electronic)9781439807156
ISBN (Print)9781439807149
DOIs
StatePublished - Jan 1 2012

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Restless Legs Syndrome
Sleep
Extremities
Parkinson Disease
Wakefulness
Dyskinesias
Population
Quality of Life

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Restless legs syndrome and periodic limb movements of sleep. / Klassen, Bryan; Adler, Charles Howard.

Parkinson's Disease, Second Edition. CRC Press, 2012. p. 235-248.

Research output: Chapter in Book/Report/Conference proceedingChapter

Klassen B, Adler CH. Restless legs syndrome and periodic limb movements of sleep. In Parkinson's Disease, Second Edition. CRC Press. 2012. p. 235-248 https://doi.org/10.1201/b12948
Klassen, Bryan ; Adler, Charles Howard. / Restless legs syndrome and periodic limb movements of sleep. Parkinson's Disease, Second Edition. CRC Press, 2012. pp. 235-248
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