Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal

Jacqueline K. Limberg, Katherine R. Malterer, Luke J. Matzek, James A. Levine, Nisha Charkoudian, John M. Miles, Michael Joseph Joyner, Timothy B Curry

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Individuals with high plasma norepinephrine (NE) levels at rest have a smaller reduction in resting energy expenditure (REE) following β-adrenergic blockade. If this finding extends to the response to a meal, it could have important implications for the role of the sympathetic nervous system in energy balance and weight gain. We hypothesized high muscle sympathetic nerve activity (MSNA) would be associated with a low sympathetically mediated component of energy expenditure following a meal. Fourteen young, healthy adults completed two visits randomized to continuous saline (control) or intravenous propranolol to achieve systemic β-adrenergic blockade. Muscle sympathetic nerve activity and REE were measured (indirect calorimetry) followed by a liquid mixed meal (Ensure). Measures of energy expenditure continued every 30 min for 5 h after the meal and are reported as an area under the curve (AUC). Sympathetic support of energy expenditure was calculated as the difference between the AUC during saline and β-blockade (AUCP ropranolol–AUCS aline, β-REE) and as a percent (%) of control (AUCP ropranolol÷AUCS aline × 100). β-REE was associated with baseline sympathetic activity, such that individuals with high resting MSNA (bursts/100 heart beats) and plasma NE had the greatest sympathetically mediated component of energy expenditure following a meal (MSNA: β-REE R = −0.58, P = 0.03; %REE R = −0.56, P = 0.04; NE: β-REE R = −0.55, P = 0.0535; %REE R = −0.54, P = 0.0552). Contrary to our hypothesis, high resting sympathetic activity is associated with a greater sympathetically mediated component of energy expenditure following a liquid meal. These findings may have implications for weight maintenance in individuals with varying resting sympathetic activity.

Original languageEnglish (US)
Article numbere13389
JournalPhysiological Reports
Volume5
Issue number16
DOIs
StatePublished - Aug 1 2017

Fingerprint

Energy Metabolism
Meals
Muscles
Norepinephrine
Adrenergic Agents
Area Under Curve
Indirect Calorimetry
Sympathetic Nervous System
Propranolol
Weight Gain
Young Adult
Maintenance
Weights and Measures

Keywords

  • propranolol
  • thermic effect of food
  • β-adrenergic

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

Cite this

Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal. / Limberg, Jacqueline K.; Malterer, Katherine R.; Matzek, Luke J.; Levine, James A.; Charkoudian, Nisha; Miles, John M.; Joyner, Michael Joseph; Curry, Timothy B.

In: Physiological Reports, Vol. 5, No. 16, e13389, 01.08.2017.

Research output: Contribution to journalArticle

Limberg, Jacqueline K. ; Malterer, Katherine R. ; Matzek, Luke J. ; Levine, James A. ; Charkoudian, Nisha ; Miles, John M. ; Joyner, Michael Joseph ; Curry, Timothy B. / Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal. In: Physiological Reports. 2017 ; Vol. 5, No. 16.
@article{499851c8963a447a943986b49e81be9f,
title = "Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal",
abstract = "Individuals with high plasma norepinephrine (NE) levels at rest have a smaller reduction in resting energy expenditure (REE) following β-adrenergic blockade. If this finding extends to the response to a meal, it could have important implications for the role of the sympathetic nervous system in energy balance and weight gain. We hypothesized high muscle sympathetic nerve activity (MSNA) would be associated with a low sympathetically mediated component of energy expenditure following a meal. Fourteen young, healthy adults completed two visits randomized to continuous saline (control) or intravenous propranolol to achieve systemic β-adrenergic blockade. Muscle sympathetic nerve activity and REE were measured (indirect calorimetry) followed by a liquid mixed meal (Ensure). Measures of energy expenditure continued every 30 min for 5 h after the meal and are reported as an area under the curve (AUC). Sympathetic support of energy expenditure was calculated as the difference between the AUC during saline and β-blockade (AUCP ropranolol–AUCS aline, β-REE) and as a percent ({\%}) of control (AUCP ropranolol÷AUCS aline × 100). β-REE was associated with baseline sympathetic activity, such that individuals with high resting MSNA (bursts/100 heart beats) and plasma NE had the greatest sympathetically mediated component of energy expenditure following a meal (MSNA: β-REE R = −0.58, P = 0.03; {\%}REE R = −0.56, P = 0.04; NE: β-REE R = −0.55, P = 0.0535; {\%}REE R = −0.54, P = 0.0552). Contrary to our hypothesis, high resting sympathetic activity is associated with a greater sympathetically mediated component of energy expenditure following a liquid meal. These findings may have implications for weight maintenance in individuals with varying resting sympathetic activity.",
keywords = "propranolol, thermic effect of food, β-adrenergic",
author = "Limberg, {Jacqueline K.} and Malterer, {Katherine R.} and Matzek, {Luke J.} and Levine, {James A.} and Nisha Charkoudian and Miles, {John M.} and Joyner, {Michael Joseph} and Curry, {Timothy B}",
year = "2017",
month = "8",
day = "1",
doi = "10.14814/phy2.13389",
language = "English (US)",
volume = "5",
journal = "Physiological Reports",
issn = "2051-817X",
publisher = "John Wiley and Sons Inc.",
number = "16",

}

TY - JOUR

T1 - Resting sympathetic activity is associated with the sympathetically mediated component of energy expenditure following a meal

AU - Limberg, Jacqueline K.

AU - Malterer, Katherine R.

AU - Matzek, Luke J.

AU - Levine, James A.

AU - Charkoudian, Nisha

AU - Miles, John M.

AU - Joyner, Michael Joseph

AU - Curry, Timothy B

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Individuals with high plasma norepinephrine (NE) levels at rest have a smaller reduction in resting energy expenditure (REE) following β-adrenergic blockade. If this finding extends to the response to a meal, it could have important implications for the role of the sympathetic nervous system in energy balance and weight gain. We hypothesized high muscle sympathetic nerve activity (MSNA) would be associated with a low sympathetically mediated component of energy expenditure following a meal. Fourteen young, healthy adults completed two visits randomized to continuous saline (control) or intravenous propranolol to achieve systemic β-adrenergic blockade. Muscle sympathetic nerve activity and REE were measured (indirect calorimetry) followed by a liquid mixed meal (Ensure). Measures of energy expenditure continued every 30 min for 5 h after the meal and are reported as an area under the curve (AUC). Sympathetic support of energy expenditure was calculated as the difference between the AUC during saline and β-blockade (AUCP ropranolol–AUCS aline, β-REE) and as a percent (%) of control (AUCP ropranolol÷AUCS aline × 100). β-REE was associated with baseline sympathetic activity, such that individuals with high resting MSNA (bursts/100 heart beats) and plasma NE had the greatest sympathetically mediated component of energy expenditure following a meal (MSNA: β-REE R = −0.58, P = 0.03; %REE R = −0.56, P = 0.04; NE: β-REE R = −0.55, P = 0.0535; %REE R = −0.54, P = 0.0552). Contrary to our hypothesis, high resting sympathetic activity is associated with a greater sympathetically mediated component of energy expenditure following a liquid meal. These findings may have implications for weight maintenance in individuals with varying resting sympathetic activity.

AB - Individuals with high plasma norepinephrine (NE) levels at rest have a smaller reduction in resting energy expenditure (REE) following β-adrenergic blockade. If this finding extends to the response to a meal, it could have important implications for the role of the sympathetic nervous system in energy balance and weight gain. We hypothesized high muscle sympathetic nerve activity (MSNA) would be associated with a low sympathetically mediated component of energy expenditure following a meal. Fourteen young, healthy adults completed two visits randomized to continuous saline (control) or intravenous propranolol to achieve systemic β-adrenergic blockade. Muscle sympathetic nerve activity and REE were measured (indirect calorimetry) followed by a liquid mixed meal (Ensure). Measures of energy expenditure continued every 30 min for 5 h after the meal and are reported as an area under the curve (AUC). Sympathetic support of energy expenditure was calculated as the difference between the AUC during saline and β-blockade (AUCP ropranolol–AUCS aline, β-REE) and as a percent (%) of control (AUCP ropranolol÷AUCS aline × 100). β-REE was associated with baseline sympathetic activity, such that individuals with high resting MSNA (bursts/100 heart beats) and plasma NE had the greatest sympathetically mediated component of energy expenditure following a meal (MSNA: β-REE R = −0.58, P = 0.03; %REE R = −0.56, P = 0.04; NE: β-REE R = −0.55, P = 0.0535; %REE R = −0.54, P = 0.0552). Contrary to our hypothesis, high resting sympathetic activity is associated with a greater sympathetically mediated component of energy expenditure following a liquid meal. These findings may have implications for weight maintenance in individuals with varying resting sympathetic activity.

KW - propranolol

KW - thermic effect of food

KW - β-adrenergic

UR - http://www.scopus.com/inward/record.url?scp=85028728856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028728856&partnerID=8YFLogxK

U2 - 10.14814/phy2.13389

DO - 10.14814/phy2.13389

M3 - Article

C2 - 28867675

AN - SCOPUS:85028728856

VL - 5

JO - Physiological Reports

JF - Physiological Reports

SN - 2051-817X

IS - 16

M1 - e13389

ER -