Responses of the stenosed and contralateral kidneys to [Sar1, Thr8] AII in human renovascular hypertension

Stephen C Textor, A. Novick, S. K. Mujais, R. Ross, E. L. Bravo, F. M. Fouad, R. C. Tarazi

Research output: Contribution to journalArticle

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Abstract

To better define the intrarenal hemodynamic effects of angiotensin in human renovascular hypertension, 10 patients underwent renal hemodynamic and functional measurements before and during fusion of a competitive angiotensin analog, [Sar1, Thr8] AII. Eight had technically satisfactory split function studies. Despite a fall in mean arterial pressure (132 ± 6 to 121 ± 6 mm Hg, p < 0.05) and humoral changes consistent with angiotensin-mediated hypertension, the intrarenal effects of this analog were commonly those of an angiotensin agonist, producing vasoconstriction and sodium retention. This was quantitatively greatest in the contralateral kidney, whose preinfusion sodium excretion (86 ± 30 μEq/min vs 25 ± 9 μEq/min, p < 0.02) and glomerular filtration rate (76 ± 7 ml/min vs 41 ± 7 ml/min, p < 0.01) were higher than the stenotic kidney. In some cases, an increase in renal blood flow and rise in sodium excretion were evident during angiotensin blockade, suggesting a tonic intrarenal action of angiotensin. Although renin veins renin values differed markedly between the stenotic and contralateral kidney (ratio = 2.05 ± 0.30), relative changes in effective renal plasma flow were correlated (r = 0.84; p < 0.01) during infusion of this analog. These results underscore the differences in sensitivities between vascular beds to the effects of angiotensin II and the major role of the contralateral kidney in renal function and sodium homeostasis in human renovascular hypertension.

Original languageEnglish (US)
Pages (from-to)796-804
Number of pages9
JournalHypertension
Volume5
Issue number5 I
StatePublished - 1983
Externally publishedYes

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Renovascular Hypertension
Angiotensins
Kidney
Sodium
Renin
Hemodynamics
Effective Renal Plasma Flow
Renal Circulation
Vasoconstriction
Glomerular Filtration Rate
Angiotensin II
Blood Vessels
Veins
Arterial Pressure
Homeostasis
Hypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Textor, S. C., Novick, A., Mujais, S. K., Ross, R., Bravo, E. L., Fouad, F. M., & Tarazi, R. C. (1983). Responses of the stenosed and contralateral kidneys to [Sar1, Thr8] AII in human renovascular hypertension. Hypertension, 5(5 I), 796-804.

Responses of the stenosed and contralateral kidneys to [Sar1, Thr8] AII in human renovascular hypertension. / Textor, Stephen C; Novick, A.; Mujais, S. K.; Ross, R.; Bravo, E. L.; Fouad, F. M.; Tarazi, R. C.

In: Hypertension, Vol. 5, No. 5 I, 1983, p. 796-804.

Research output: Contribution to journalArticle

Textor, SC, Novick, A, Mujais, SK, Ross, R, Bravo, EL, Fouad, FM & Tarazi, RC 1983, 'Responses of the stenosed and contralateral kidneys to [Sar1, Thr8] AII in human renovascular hypertension', Hypertension, vol. 5, no. 5 I, pp. 796-804.
Textor, Stephen C ; Novick, A. ; Mujais, S. K. ; Ross, R. ; Bravo, E. L. ; Fouad, F. M. ; Tarazi, R. C. / Responses of the stenosed and contralateral kidneys to [Sar1, Thr8] AII in human renovascular hypertension. In: Hypertension. 1983 ; Vol. 5, No. 5 I. pp. 796-804.
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