Response of patients with indolent systemic mastocytosis to tamoxifen citrate

Joseph H. Butterfield, Dong Chen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We examined whether tamoxifen citrate at 20mg/day for 1 year had a beneficial effect on laboratory findings, bone marrow mastocytosis, common clinical symptoms, or quality-of-life assessment for 5 women and 2 men with indolent systemic mastocytosis. Tamoxifen was well tolerated. We found significant reductions in the platelet count, serum alkaline phosphatase, and 24-h urinary excretion of N-methylhistamine and significant increases in serum lactate dehydrogenase and (excluding 2 patients taking aspirin) in 24-h urinary excretion of 11β-prostaglandin F. Overall, no change occurred in percent involvement of bone marrow by mastocytosis. Symptom scores were mild and did not change during the treatment. The 36-Item Short Form Health Survey scores for quality of life physical and mental components showed no marked changes. Tamoxifen, an older, nonhematotoxic medication, has limited activity in systemic mastocytosis at the dosage used in this study.

Original languageEnglish (US)
JournalLeukemia Research
DOIs
StateAccepted/In press - Aug 26 2015

Keywords

  • 11β-prostaglandin F
  • N-Methylhistamine
  • Systemic mastocytosis
  • Tamoxifen
  • Tryptase

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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