Response assessment in Waldenström macroglobulinaemia: Update from the VIth International Workshop

Roger G. Owen, Robert A. Kyle, Marvin J. Stone, Andy C. Rawstron, Veronique Leblond, Giampaolo Merlini, Ramon Garcia-Sanz, Enrique M. Ocio, Enrica Morra, Pierre Morel, Kenneth C. Anderson, Christopher J. Patterson, Nikhil C. Munshi, Alessandra Tedeschi, Douglas E. Joshua, Efstathios Kastritis, Evangelos Terpos, Irene M. Ghobrial, Xavier Leleu, Morie A. GertzStephen M. Ansell, William G. Morice, Eva Kimby, Steven P. Treon

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Abstract

This report represents a further update of the consensus panel criteria for the assessment of clinical response in patients with Waldenström macroglobulinaemia (WM). These criteria have been updated in light of further data demonstrating an improvement in categorical responses with new drug regimens as well as acknowledgement of the fact that such responses are predictive of overall outcome. A number of key changes are proposed but challenges do however remain and these include the variability in kinetics of immunoglobulin M (IgM) reduction with different treatment modalities and the apparent discrepancy between IgM and bone marrow/tissue response noted with some regimens. Planned sequential bone marrow assessments are encouraged in clinical trials.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalBritish journal of haematology
Volume160
Issue number2
DOIs
StatePublished - Jan 1 2013

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Keywords

  • Residual disease
  • Trials
  • Waldenström macroglobulinaemia

ASJC Scopus subject areas

  • Hematology

Cite this

Owen, R. G., Kyle, R. A., Stone, M. J., Rawstron, A. C., Leblond, V., Merlini, G., Garcia-Sanz, R., Ocio, E. M., Morra, E., Morel, P., Anderson, K. C., Patterson, C. J., Munshi, N. C., Tedeschi, A., Joshua, D. E., Kastritis, E., Terpos, E., Ghobrial, I. M., Leleu, X., ... Treon, S. P. (2013). Response assessment in Waldenström macroglobulinaemia: Update from the VIth International Workshop. British journal of haematology, 160(2), 171-176. https://doi.org/10.1111/bjh.12102