Respiratory muscle plasticity

Katharine L. Rowley, Carlos Bernardo Mantilla, Gary C Sieck

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Plasticity of respiratory muscles must be considered in the context of their unique physiological demands. The continuous rhythmic activation of respiratory muscles makes them among the most active in the body. Respiratory muscles, especially the diaphragm, are non-weight-bearing, and thus, in contrast to limb muscles, are not exposed to gravitational effects. Perturbations in normal activation and load known to induce plasticity in limb muscles may not cause similar adaptations in respiratory muscles. In this review, we explore the structural and functional properties of the diaphragm muscle and their response to alterations in load and activity. Overall, relatively modest changes in diaphragm structural and functional properties occur in response to perturbations in load or activity. However, disruptions in the normal influence of phrenic innervation by frank denervation, tetrodotoxin nerve block and spinal hemisection, induce profound changes in the diaphragm, indicating the substantial trophic influence of phrenic motoneurons on diaphragm muscle.

Original languageEnglish (US)
Pages (from-to)235-251
Number of pages17
JournalRespiratory Physiology and Neurobiology
Volume147
Issue number2-3 SPEC. ISS.
DOIs
StatePublished - Jul 28 2005

Fingerprint

Respiratory Muscles
Diaphragm
Muscles
Extremities
Nerve Block
Tetrodotoxin
Motor Neurons
Denervation

Keywords

  • Diaphragm
  • Inactivity
  • Perturbations
  • Plasticity
  • Respiratory muscles

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Respiratory muscle plasticity. / Rowley, Katharine L.; Mantilla, Carlos Bernardo; Sieck, Gary C.

In: Respiratory Physiology and Neurobiology, Vol. 147, No. 2-3 SPEC. ISS., 28.07.2005, p. 235-251.

Research output: Contribution to journalArticle

Rowley, Katharine L. ; Mantilla, Carlos Bernardo ; Sieck, Gary C. / Respiratory muscle plasticity. In: Respiratory Physiology and Neurobiology. 2005 ; Vol. 147, No. 2-3 SPEC. ISS. pp. 235-251.
@article{7c7b4afafade4239951480af88be48e4,
title = "Respiratory muscle plasticity",
abstract = "Plasticity of respiratory muscles must be considered in the context of their unique physiological demands. The continuous rhythmic activation of respiratory muscles makes them among the most active in the body. Respiratory muscles, especially the diaphragm, are non-weight-bearing, and thus, in contrast to limb muscles, are not exposed to gravitational effects. Perturbations in normal activation and load known to induce plasticity in limb muscles may not cause similar adaptations in respiratory muscles. In this review, we explore the structural and functional properties of the diaphragm muscle and their response to alterations in load and activity. Overall, relatively modest changes in diaphragm structural and functional properties occur in response to perturbations in load or activity. However, disruptions in the normal influence of phrenic innervation by frank denervation, tetrodotoxin nerve block and spinal hemisection, induce profound changes in the diaphragm, indicating the substantial trophic influence of phrenic motoneurons on diaphragm muscle.",
keywords = "Diaphragm, Inactivity, Perturbations, Plasticity, Respiratory muscles",
author = "Rowley, {Katharine L.} and Mantilla, {Carlos Bernardo} and Sieck, {Gary C}",
year = "2005",
month = "7",
day = "28",
doi = "10.1016/j.resp.2005.03.003",
language = "English (US)",
volume = "147",
pages = "235--251",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "2-3 SPEC. ISS.",

}

TY - JOUR

T1 - Respiratory muscle plasticity

AU - Rowley, Katharine L.

AU - Mantilla, Carlos Bernardo

AU - Sieck, Gary C

PY - 2005/7/28

Y1 - 2005/7/28

N2 - Plasticity of respiratory muscles must be considered in the context of their unique physiological demands. The continuous rhythmic activation of respiratory muscles makes them among the most active in the body. Respiratory muscles, especially the diaphragm, are non-weight-bearing, and thus, in contrast to limb muscles, are not exposed to gravitational effects. Perturbations in normal activation and load known to induce plasticity in limb muscles may not cause similar adaptations in respiratory muscles. In this review, we explore the structural and functional properties of the diaphragm muscle and their response to alterations in load and activity. Overall, relatively modest changes in diaphragm structural and functional properties occur in response to perturbations in load or activity. However, disruptions in the normal influence of phrenic innervation by frank denervation, tetrodotoxin nerve block and spinal hemisection, induce profound changes in the diaphragm, indicating the substantial trophic influence of phrenic motoneurons on diaphragm muscle.

AB - Plasticity of respiratory muscles must be considered in the context of their unique physiological demands. The continuous rhythmic activation of respiratory muscles makes them among the most active in the body. Respiratory muscles, especially the diaphragm, are non-weight-bearing, and thus, in contrast to limb muscles, are not exposed to gravitational effects. Perturbations in normal activation and load known to induce plasticity in limb muscles may not cause similar adaptations in respiratory muscles. In this review, we explore the structural and functional properties of the diaphragm muscle and their response to alterations in load and activity. Overall, relatively modest changes in diaphragm structural and functional properties occur in response to perturbations in load or activity. However, disruptions in the normal influence of phrenic innervation by frank denervation, tetrodotoxin nerve block and spinal hemisection, induce profound changes in the diaphragm, indicating the substantial trophic influence of phrenic motoneurons on diaphragm muscle.

KW - Diaphragm

KW - Inactivity

KW - Perturbations

KW - Plasticity

KW - Respiratory muscles

UR - http://www.scopus.com/inward/record.url?scp=23444443866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23444443866&partnerID=8YFLogxK

U2 - 10.1016/j.resp.2005.03.003

DO - 10.1016/j.resp.2005.03.003

M3 - Article

C2 - 15871925

AN - SCOPUS:23444443866

VL - 147

SP - 235

EP - 251

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 2-3 SPEC. ISS.

ER -